ENSG00000065559


Homo sapiens

Features
Gene ID: ENSG00000065559
  
Biological name :MAP2K4
  
Synonyms : MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p12
Gene start: 12020824
Gene end: 12143830
  
Corresponding Affymetrix probe sets: 203265_s_at (Human Genome U133 Plus 2.0 Array)   203266_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473606
Ensembl peptide - ENSP00000473511
Ensembl peptide - ENSP00000473582
Ensembl peptide - ENSP00000262445
Ensembl peptide - ENSP00000410402
Ensembl peptide - ENSP00000463507
Ensembl peptide - ENSP00000467239
Ensembl peptide - ENSP00000473458
Ensembl peptide - ENSP00000473472
NCBI entrez gene - 6416     See in Manteia.
OMIM - 601335
RefSeq - XM_011523977
RefSeq - NM_001281435
RefSeq - NM_003010
RefSeq - XM_005256753
RefSeq - XM_005256755
RefSeq - XM_011523976
RefSeq Peptide - NP_001268364
RefSeq Peptide - NP_003001
swissprot - K7EP58
swissprot - P45985
swissprot - J3QLE2
swissprot - R4GN68
swissprot - R4GN37
Ensembl - ENSG00000065559
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k4aENSDARG00000063583Danio rerio
 map2k4bENSDARG00000077177Danio rerio
 MAP2K4ENSGALG00000032178Gallus gallus
 Map2k4ENSMUSG00000033352Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6ENSG0000010898445
MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3ENSG0000003415243
MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7ENSG0000007698442
MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2ENSG0000012693433
MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1ENSG0000016903232
MAP2K5 / Q13163 / mitogen-activated protein kinase kinase 5ENSG0000013776431
AC011005.1ENSG0000023062629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035897 proteolysis in other organism TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0072709 cellular response to sorbitol IEA
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008545 JUN kinase kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / reaction
 ENSG00000109339 MAPK10 / P53779 / mitogen-activated protein kinase 10  / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000050748 MAPK9 / P45984 / mitogen-activated protein kinase 9  / reaction
 ENSG00000197442 MAP3K5 / Q99683 / mitogen-activated protein kinase kinase kinase 5  / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction
 ENSG00000095015 MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1  / reaction






 

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