ENSG00000050748


Homo sapiens

Features
Gene ID: ENSG00000050748
  
Biological name :MAPK9
  
Synonyms : MAPK9 / mitogen-activated protein kinase 9 / P45984
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.3
Gene start: 180233143
Gene end: 180292099
  
Corresponding Affymetrix probe sets: 203218_at (Human Genome U133 Plus 2.0 Array)   210570_x_at (Human Genome U133 Plus 2.0 Array)   225781_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394560
Ensembl peptide - ENSP00000389338
Ensembl peptide - ENSP00000397422
Ensembl peptide - ENSP00000443149
Ensembl peptide - ENSP00000430608
Ensembl peptide - ENSP00000321410
Ensembl peptide - ENSP00000345524
Ensembl peptide - ENSP00000377028
Ensembl peptide - ENSP00000377029
Ensembl peptide - ENSP00000380262
NCBI entrez gene - 5601     See in Manteia.
OMIM - 602896
RefSeq - XM_017009643
RefSeq - NM_002752
RefSeq - NM_139068
RefSeq - NM_139069
RefSeq - NM_139070
RefSeq - XM_005265940
RefSeq - XM_006714891
RefSeq - XM_017009638
RefSeq - XM_017009639
RefSeq - XM_017009640
RefSeq - XM_017009641
RefSeq - XM_017009642
RefSeq - NM_001135044
RefSeq - NM_001308244
RefSeq Peptide - NP_001295173
RefSeq Peptide - NP_002743
RefSeq Peptide - NP_620707
RefSeq Peptide - NP_620708
RefSeq Peptide - NP_620709
RefSeq Peptide - NP_001128516
swissprot - D7R528
swissprot - J3KNK1
swissprot - E5RJ57
swissprot - P45984
swissprot - D7R525
Ensembl - ENSG00000050748
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk9ENSDARG00000077364Danio rerio
 MAPK9ENSGALG00000039099Gallus gallus
 Mapk9ENSMUSG00000020366Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK10 / P53779 / mitogen-activated protein kinase 10ENSG0000010933984
MAPK8 / P45983 / mitogen-activated protein kinase 8ENSG0000010764383
MAPK14 / Q16539 / mitogen-activated protein kinase 14ENSG0000011206242
MAPK11 / Q15759 / mitogen-activated protein kinase 11ENSG0000018538642
MAPK13 / O15264 / mitogen-activated protein kinase 13ENSG0000015671140
MAPK12 / P53778 / mitogen-activated protein kinase 12ENSG0000018813040


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008351  Mitogen-activated protein (MAP) kinase, JNK
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007258 JUN phosphorylation IEA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0061833 protein localization to tricellular tight junction IEA
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071310 cellular response to organic substance IBA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004705 JUN kinase activity IDA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000177606 JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunit  / reaction
 ENSG00000115966 ATF2 / P15336 / activating transcription factor 2  / reaction
 ENSG00000065559 MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4  / reaction
 ENSG00000076984 MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7  / reaction






 

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