ENSG00000076984


Homo sapiens

Features
Gene ID: ENSG00000076984
  
Biological name :MAP2K7
  
Synonyms : MAP2K7 / mitogen-activated protein kinase kinase 7 / O14733
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 7903843
Gene end: 7914478
  
Corresponding Affymetrix probe sets: 209951_s_at (Human Genome U133 Plus 2.0 Array)   209952_s_at (Human Genome U133 Plus 2.0 Array)   216206_x_at (Human Genome U133 Plus 2.0 Array)   226023_at (Human Genome U133 Plus 2.0 Array)   226053_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381066
Ensembl peptide - ENSP00000381068
Ensembl peptide - ENSP00000381070
NCBI entrez gene - 5609     See in Manteia.
OMIM - 603014
RefSeq - XM_006722800
RefSeq - NM_001297555
RefSeq - NM_001297556
RefSeq - NM_145185
RefSeq Peptide - NP_001284485
RefSeq Peptide - NP_660186
RefSeq Peptide - NP_001284484
swissprot - O14733
Ensembl - ENSG00000076984
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k7ENSDARG00000008279Danio rerio
 Map2k7ENSMUSG00000002948Mus musculus
 Map2k7ENSMUSG00000109061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4ENSG0000006555940
MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6ENSG0000010898434
MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3ENSG0000003415232
MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2ENSG0000012693430
MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1ENSG0000016903229
MAP2K5 / Q13163 / mitogen-activated protein kinase kinase 5ENSG0000013776427
AC011005.1ENSG0000023062627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006970 response to osmotic stress IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007257 activation of JUN kinase activity ISS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009408 response to heat IDA
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0035897 proteolysis in other organism TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:1904355 positive regulation of telomere capping IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000109339 MAPK10 / P53779 / mitogen-activated protein kinase 10  / reaction
 ENSG00000050748 MAPK9 / P45984 / mitogen-activated protein kinase 9  / reaction
 ENSG00000095015 MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1  / reaction






 

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