ENSG00000137764


Homo sapiens

Features
Gene ID: ENSG00000137764
  
Biological name :MAP2K5
  
Synonyms : MAP2K5 / mitogen-activated protein kinase kinase 5 / Q13163
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q23
Gene start: 67542709
Gene end: 67807123
  
Corresponding Affymetrix probe sets: 204756_at (Human Genome U133 Plus 2.0 Array)   210482_x_at (Human Genome U133 Plus 2.0 Array)   211370_s_at (Human Genome U133 Plus 2.0 Array)   211371_at (Human Genome U133 Plus 2.0 Array)   216435_at (Human Genome U133 Plus 2.0 Array)   216765_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000178640
Ensembl peptide - ENSP00000483771
Ensembl peptide - ENSP00000480580
Ensembl peptide - ENSP00000390196
Ensembl peptide - ENSP00000378859
Ensembl peptide - ENSP00000346493
Ensembl peptide - ENSP00000342101
NCBI entrez gene - 5607     See in Manteia.
OMIM - 602520
RefSeq - XM_011521788
RefSeq - NM_001206804
RefSeq - NM_002757
RefSeq - NM_145160
RefSeq - XM_011521787
RefSeq Peptide - NP_001193733
RefSeq Peptide - NP_002748
RefSeq Peptide - NP_660143
swissprot - A0A087WWX7
swissprot - A0A024R5Y2
swissprot - A0A024R5X5
swissprot - H7BZL1
swissprot - A0A087X0Z8
swissprot - Q13163
swissprot - A6NK28
Ensembl - ENSG00000137764
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k5ENSDARG00000011851Danio rerio
 MAP2K5ENSGALG00000007930Gallus gallus
 Map2k5ENSMUSG00000058444Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2ENSG0000012693433
AC011005.1ENSG0000023062632
MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1ENSG0000016903232
MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6ENSG0000010898429
MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4ENSG0000006555928
MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3ENSG0000003415228
MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7ENSG0000007698427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034851  Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion ISS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051247 positive regulation of protein metabolic process ISS
 biological_processGO:0060761 negative regulation of response to cytokine stimulus ISS
 biological_processGO:0070375 ERK5 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus ISS
 biological_processGO:0071499 cellular response to laminar fluid shear stress TAS
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis ISS
 biological_processGO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production ISS
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signalling to ERK5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / reaction






 

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