ENSG00000166484


Homo sapiens

Features
Gene ID: ENSG00000166484
  
Biological name :MAPK7
  
Synonyms : MAPK7 / mitogen-activated protein kinase 7 / Q13164
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p11.2
Gene start: 19377721
Gene end: 19383544
  
Corresponding Affymetrix probe sets: 207292_s_at (Human Genome U133 Plus 2.0 Array)   35617_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462804
Ensembl peptide - ENSP00000458146
Ensembl peptide - ENSP00000462819
Ensembl peptide - ENSP00000474397
Ensembl peptide - ENSP00000299612
Ensembl peptide - ENSP00000311005
Ensembl peptide - ENSP00000378966
Ensembl peptide - ENSP00000378968
Ensembl peptide - ENSP00000412902
NCBI entrez gene - 5598     See in Manteia.
OMIM - 602521
RefSeq - XM_011523957
RefSeq - NM_002749
RefSeq - NM_139032
RefSeq - NM_139033
RefSeq - NM_139034
RefSeq - XM_006721557
RefSeq - XM_006721558
RefSeq - XM_006721559
RefSeq Peptide - NP_002740
RefSeq Peptide - NP_620603
RefSeq Peptide - NP_620601
RefSeq Peptide - NP_620602
swissprot - J3KT61
swissprot - Q13164
swissprot - A0A024QZ20
swissprot - S4R3I1
swissprot - C9JUK9
swissprot - I3L0J8
swissprot - J3KT50
Ensembl - ENSG00000166484
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk7ENSDARG00000023110Danio rerio
 Mapk7ENSMUSG00000001034Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK6 / Q16659 / mitogen-activated protein kinase 6ENSG0000006995622
MAPK3 / P27361 / mitogen-activated protein kinase 3ENSG0000010288222
MAPK1 / P28482 / mitogen-activated protein kinase 1ENSG0000010003022
NLK / Q9UBE8 / nemo like kinaseENSG0000008709521
MAPK15 / Q8TD08 / mitogen-activated protein kinase 15ENSG0000018108520
MAPK4 / P31152 / mitogen-activated protein kinase 4ENSG0000014163918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0019933 cAMP-mediated signaling NAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030821 obsolete negative regulation of cAMP catabolic process NAS
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IGI
 biological_processGO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0050728 negative regulation of inflammatory response TAS
 biological_processGO:0051247 positive regulation of protein metabolic process IGI
 biological_processGO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity NAS
 biological_processGO:0060761 negative regulation of response to cytokine stimulus IGI
 biological_processGO:0070301 cellular response to hydrogen peroxide IMP
 biological_processGO:0070377 negative regulation of ERK5 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IGI
 biological_processGO:0071499 cellular response to laminar fluid shear stress TAS
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IPI


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
Signalling to ERK5
ERKs are inactivated
Senescence-Associated Secretory Phenotype (SASP)
Gastrin-CREB signalling pathway via PKC and MAPK
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137764 MAP2K5 / Q13163 / mitogen-activated protein kinase kinase 5  / reaction
 ENSG00000108861 DUSP3 / P51452 / dual specificity phosphatase 3  / reaction
 ENSG00000120875 DUSP4 / Q13115 / dual specificity phosphatase 4  / reaction
 ENSG00000112640 Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit Bdelta  / reaction
 ENSG00000177189 P51812 / RPS6KA3 / ribosomal protein S6 kinase A3  / reaction
 ENSG00000081189 MEF2C / Q06413 / myocyte enhancer factor 2C  / reaction
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / complex
 ENSG00000068305 MEF2A / Q02078 / myocyte enhancer factor 2A  / reaction
 ENSG00000071242 Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2  / reaction
 ENSG00000117676 Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1  / reaction
 ENSG00000139318 DUSP6 / Q16828 / dual specificity phosphatase 6  / reaction
 ENSG00000164086 DUSP7 / Q16829 / dual specificity phosphatase 7  / reaction






 

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