ENSG00000141639


Homo sapiens

Features
Gene ID: ENSG00000141639
  
Biological name :MAPK4
  
Synonyms : MAPK4 / mitogen-activated protein kinase 4 / P31152
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q21.1
Gene start: 50560078
Gene end: 50731824
  
Corresponding Affymetrix probe sets: 204707_s_at (Human Genome U133 Plus 2.0 Array)   204708_at (Human Genome U133 Plus 2.0 Array)   230732_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466233
Ensembl peptide - ENSP00000383234
Ensembl peptide - ENSP00000439231
Ensembl peptide - ENSP00000465661
NCBI entrez gene - 5596     See in Manteia.
OMIM - 176949
RefSeq - XM_017025839
RefSeq - NM_001292040
RefSeq - NM_002747
RefSeq - XM_005258299
RefSeq - XM_011526074
RefSeq - XM_011526075
RefSeq - XM_011526076
RefSeq - XM_011526077
RefSeq - NM_001292039
RefSeq Peptide - NP_002738
RefSeq Peptide - NP_001278968
RefSeq Peptide - NP_001278969
swissprot - B4DEW2
swissprot - P31152
swissprot - K7EN18
swissprot - K7ELV1
Ensembl - ENSG00000141639
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk4ENSDARG00000110581Danio rerio
 Mapk4ENSMUSG00000024558Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK6 / Q16659 / mitogen-activated protein kinase 6ENSG0000006995656
MAPK7 / Q13164 / mitogen-activated protein kinase 7ENSG0000016648425
MAPK1 / P28482 / mitogen-activated protein kinase 1ENSG0000010003024
MAPK15 / Q8TD08 / mitogen-activated protein kinase 15ENSG0000018108524
MAPK3 / P27361 / mitogen-activated protein kinase 3ENSG0000010288224
NLK / Q9UBE8 / nemo like kinaseENSG0000008709520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008350  Mitogen-activated protein (MAP) kinase, ERK3/4
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0071310 cellular response to organic substance IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / complex / reaction






 

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