ENSG00000089022


Homo sapiens

Features
Gene ID: ENSG00000089022
  
Biological name :MAPKAPK5
  
Synonyms : MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.12
Gene start: 111841978
Gene end: 111902238
  
Corresponding Affymetrix probe sets: 212871_at (Human Genome U133 Plus 2.0 Array)   228925_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449381
Ensembl peptide - ENSP00000473467
Ensembl peptide - ENSP00000473541
Ensembl peptide - ENSP00000448408
Ensembl peptide - ENSP00000449667
NCBI entrez gene - 8550     See in Manteia.
OMIM - 606723
RefSeq - XM_017020139
RefSeq - NM_003668
RefSeq - NM_139078
RefSeq - XM_017020133
RefSeq - XM_017020134
RefSeq - XM_017020135
RefSeq - XM_017020136
RefSeq - XM_017020137
RefSeq - XM_017020138
RefSeq - XM_017020125
RefSeq - XM_017020126
RefSeq - XM_017020127
RefSeq - XM_017020128
RefSeq - XM_017020129
RefSeq - XM_017020130
RefSeq - XM_017020131
RefSeq - XM_017020132
RefSeq Peptide - NP_003659
RefSeq Peptide - NP_620777
swissprot - Q8IW41
swissprot - R4GN33
swissprot - R4GN93
swissprot - F8VRP2
Ensembl - ENSG00000089022
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk5ENSDARG00000028082Danio rerio
 MAPKAPK5ENSGALG00000004743Gallus gallus
 Gm42878ENSMUSG00000105340Mus musculus
 O54992ENSMUSG00000029454Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2ENSG0000016288933
Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3ENSG0000011473832
MKNK2 / Q9HBH9 / MAP kinase interacting serine/threonine kinase 2ENSG0000009987524
MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1ENSG0000007927723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006417 regulation of translation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0090400 stress-induced premature senescence IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1904355 positive regulation of telomere capping IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / reaction / complex
 ENSG00000160145 KALRN / O60229 / kalirin RhoGEF kinase  / complex / reaction
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / complex / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / reaction
 ENSG00000106211 HSPB1 / P04792 / heat shock protein family B (small) member 1  / reaction
 ENSG00000150907 FOXO1 / Q12778 / forkhead box O1  / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / complex
 ENSG00000118689 FOXO3 / O43524 / forkhead box O3  / reaction
 ENSG00000141639 MAPK4 / P31152 / mitogen-activated protein kinase 4  / complex / reaction
 ENSG00000149798 O14613 / CDC42EP2 / CDC42 effector protein 2  / reaction
 ENSG00000167617 Q6NZY7 / CDC42EP5 / CDC42 effector protein 5  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / complex
 ENSG00000163171 Q9UKI2 / CDC42EP3 / CDC42 effector protein 3  / reaction
 ENSG00000122545 SEPT7 / Q16181 / septin 7  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction






 

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