ENSG00000079277


Homo sapiens

Features
Gene ID: ENSG00000079277
  
Biological name :MKNK1
  
Synonyms : MAP kinase interacting serine/threonine kinase 1 / MKNK1 / Q9BUB5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p33
Gene start: 46557408
Gene end: 46616843
  
Corresponding Affymetrix probe sets: 1560720_at (Human Genome U133 Plus 2.0 Array)   209467_s_at (Human Genome U133 Plus 2.0 Array)   243256_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431985
Ensembl peptide - ENSP00000411135
Ensembl peptide - ENSP00000432369
Ensembl peptide - ENSP00000436709
Ensembl peptide - ENSP00000435163
Ensembl peptide - ENSP00000435069
Ensembl peptide - ENSP00000434834
Ensembl peptide - ENSP00000434493
Ensembl peptide - ENSP00000434051
Ensembl peptide - ENSP00000434021
Ensembl peptide - ENSP00000433038
Ensembl peptide - ENSP00000339573
Ensembl peptide - ENSP00000361013
Ensembl peptide - ENSP00000361014
NCBI entrez gene - 8569     See in Manteia.
OMIM - 606724
RefSeq - XM_017002667
RefSeq - XM_017002652
RefSeq - XM_017002653
RefSeq - XM_017002654
RefSeq - XM_017002655
RefSeq - XM_017002656
RefSeq - XM_017002657
RefSeq - XM_017002658
RefSeq - XM_017002659
RefSeq - XM_017002660
RefSeq - XM_017002661
RefSeq - XM_017002662
RefSeq - XM_017002663
RefSeq - XM_017002664
RefSeq - XM_017002665
RefSeq - XM_017002666
RefSeq - NM_001135553
RefSeq - NM_003684
RefSeq - NM_198973
RefSeq - XM_006711000
RefSeq - XM_006711001
RefSeq - XM_006711002
RefSeq - XM_006711003
RefSeq - XM_006711006
RefSeq - XM_006711007
RefSeq - XM_006711009
RefSeq - XM_006711013
RefSeq - XM_006711014
RefSeq - XM_006711015
RefSeq Peptide - NP_001129025
RefSeq Peptide - NP_003675
RefSeq Peptide - NP_945324
swissprot - E9PQ23
swissprot - E9PN34
swissprot - E9PMM8
swissprot - E9PLE7
swissprot - E9PSE0
swissprot - H0YE67
swissprot - Q7Z319
swissprot - Q9BUB5
swissprot - E9PIA0
swissprot - E9PII5
swissprot - E9PSC9
swissprot - E9PQ26
Ensembl - ENSG00000079277
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mknk1ENSDARG00000018411Danio rerio
 MKNK1ENSGALG00000010440Gallus gallus
 Mknk1ENSMUSG00000028708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MKNK2 / Q9HBH9 / MAP kinase interacting serine/threonine kinase 2ENSG0000009987563
P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2ENSG0000016288925
Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3ENSG0000011473824
Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5ENSG0000008902224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0046777 protein autophosphorylation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136158 SPRY2 / O43597 / sprouty RTK signaling antagonist 2  / reaction
 ENSG00000105568 P30153 / PPP2R1A / protein phosphatase 2 scaffold subunit Aalpha  / reaction
 ENSG00000113575 P67775 / PPP2CA / protein phosphatase 2 catalytic subunit alpha  / reaction
 ENSG00000104695 P62714 / PPP2CB / protein phosphatase 2 catalytic subunit beta  / reaction






 

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