ENSG00000099875


Homo sapiens

Features
Gene ID: ENSG00000099875
  
Biological name :MKNK2
  
Synonyms : MAP kinase interacting serine/threonine kinase 2 / MKNK2 / Q9HBH9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 2037465
Gene end: 2051244
  
Corresponding Affymetrix probe sets: 218205_s_at (Human Genome U133 Plus 2.0 Array)   223199_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464828
Ensembl peptide - ENSP00000465425
Ensembl peptide - ENSP00000466147
Ensembl peptide - ENSP00000466594
Ensembl peptide - ENSP00000467811
Ensembl peptide - ENSP00000250896
Ensembl peptide - ENSP00000309485
Ensembl peptide - ENSP00000465079
Ensembl peptide - ENSP00000465645
Ensembl peptide - ENSP00000466064
NCBI entrez gene - 2872     See in Manteia.
OMIM - 605069
RefSeq - NM_017572
RefSeq - NM_199054
RefSeq Peptide - NP_060042
RefSeq Peptide - NP_951009
swissprot - Q9NV89
swissprot - K7EIN7
swissprot - K7EJ98
swissprot - K7EK27
swissprot - K7ELG3
swissprot - K7ELN0
swissprot - K7EMP5
swissprot - Q9HBH9
Ensembl - ENSG00000099875
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mknk2aENSDARG00000011373Danio rerio
 mknk2bENSDARG00000015164Danio rerio
 MKNK2ENSGALG00000003845Gallus gallus
 Mknk2ENSMUSG00000020190Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1ENSG0000007927763
P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2ENSG0000016288925
Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5ENSG0000008902225
Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3ENSG0000011473825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0071243 cellular response to arsenic-containing substance IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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