ENSMUSG00000020190


Mus musculus

Features
Gene ID: ENSMUSG00000020190
  
Biological name :Mknk2
  
Synonyms : MAP kinase-interacting serine/threonine-protein kinase 2 / Mknk2 / Q8CDB0
  
Possible biological names infered from orthology : MAP kinase interacting serine/threonine kinase 2 / Q9HBH9
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80665327
Gene end: 80678112
  
Corresponding Affymetrix probe sets: 10370931 (MoGene1.0st)   1418300_a_at (Mouse Genome 430 2.0 Array)   1449029_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003433
Ensembl peptide - ENSMUSP00000143679
Ensembl peptide - ENSMUSP00000143655
Ensembl peptide - ENSMUSP00000143508
Ensembl peptide - ENSMUSP00000142388
NCBI entrez gene - 17347     See in Manteia.
MGI - MGI:894279
RefSeq - XM_017313824
RefSeq - NM_021462
RefSeq - XM_006513316
RefSeq Peptide - NP_067437
swissprot - A0A0G2JGS6
swissprot - A0A0R4IZX7
swissprot - Q8CDB0
swissprot - A0A0G2JGQ2
swissprot - A0A0G2JDJ0
Ensembl - ENSMUSG00000020190
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mknk2aENSDARG00000011373Danio rerio
 mknk2bENSDARG00000015164Danio rerio
 MKNK2ENSGALG00000003845Gallus gallus
 MKNK2ENSG00000099875Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mknk1 / MAP kinase-interacting serine/threonine kinase 1 / Q9BUB5*ENSMUSG0000002870865
Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*ENSMUSG0000003257726
P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*ENSMUSG0000001652825
Gm42878 / Q8IW41* / MAPKAPK5* / mitogen-activated protein kinase-activated protein kinase 5*ENSMUSG0000010534025
O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*ENSMUSG0000002945425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0071243 cellular response to arsenic-containing substance IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mknk1tm1Fuku/Mknk1tm1Fuku,Mknk2tm1Fuku/Mknk2tm1Fuku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mknk2tm1Fuku/Mknk2tm1Fuku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr