Manteia - Molecule gene

ENSMUSG00000029454

Mus musculus

Features

Gene ID:	ENSMUSG00000029454

Biological name :	Mapkapk5

Synonyms :	Mapkapk5 / MAP kinase-activated protein kinase 5 / O54992

Possible biological names infered from orthology :	mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	121525038
Gene end:	121545905

Corresponding Affymetrix probe sets:	10533327 (MoGene1.0st) 1417016_at (Mouse Genome 430 2.0 Array) 1443377_at (Mouse Genome 430 2.0 Array) 1458197_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000116464 Ensembl peptide - ENSMUSP00000143489 Ensembl peptide - ENSMUSP00000142346 Ensembl peptide - ENSMUSP00000031410 Ensembl peptide - ENSMUSP00000107412 Ensembl peptide - ENSMUSP00000107413 Ensembl peptide - ENSMUSP00000107416 NCBI entrez gene - 17165 See in Manteia. MGI - MGI:1333110 RefSeq - NM_010765 RefSeq Peptide - NP_034895 swissprot - O54992 swissprot - A0A0G2JGA5 swissprot - Q3UV25 swissprot - A0A0G2JDF3 swissprot - F7DD22 Ensembl - ENSMUSG00000029454

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mapkapk5	ENSDARG00000028082	Danio rerio
MAPKAPK5	ENSGALG00000004743	Gallus gallus
Q8IW41	ENSG00000089022	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gm42878 / Q8IW41* / MAPKAPK5* / mitogen-activated protein kinase-activated protein kinase 5*	ENSMUSG00000105340	99
P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*	ENSMUSG00000016528	33
Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*	ENSMUSG00000032577	32
Mknk2 / Q8CDB0 / MAP kinase-interacting serine/threonine-protein kinase 2 / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2*	ENSMUSG00000020190	25
Mknk1 / MAP kinase-interacting serine/threonine kinase 1 / Q9BUB5*	ENSMUSG00000028708	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR027442	MAP kinase activated protein kinase, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IBA
biological_process	GO:0006417	regulation of translation	ISO
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IBA
biological_process	GO:0007265	Ras protein signal transduction	IMP
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IBA
biological_process	GO:0032007	negative regulation of TOR signaling	IDA
biological_process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO
biological_process	GO:0046777	protein autophosphorylation	IBA
biological_process	GO:0051973	positive regulation of telomerase activity	ISO
biological_process	GO:0060999	positive regulation of dendritic spine development	IMP
biological_process	GO:0090400	stress-induced premature senescence	IMP
biological_process	GO:1904355	positive regulation of telomere capping	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0032156	septin cytoskeleton	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0002039	p53 binding	IDA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	ISO
molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	IBA
molecular_function	GO:0004871	obsolete signal transducer activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005516	calmodulin binding	IBA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IBA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0051019	mitogen-activated protein kinase binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002051	skin papilloma	"a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Esrrb^tm1.1Nat/Esrrb^tm1.2Nat,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL Allelic Composition: Mapkapk5^tm1Pqs/Mapkapk5⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esrrb^tm1.1Nat/Esrrb^tm1.2Nat,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Xu/Trp53^tm1Xu Genetic Background: involves: 129S4/SvJae
MP:0008009	delayed cellular replicative senescence	"slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esrrb^tm1.1Nat/Esrrb^tm1.2Nat,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL Allelic Composition: Mapkapk5^tm1Pqs/Mapkapk5⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Gabrg2^tm1Wul/Gabrg2^tm1Wul,Tg(Pcp2-cre)2Mpin/?,Tg(Pcp2-EGFP/Gabrg2)1Wul/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Mapkapk5^tm1Pqs/Mapkapk5⁺,Tg(SV40-NRASG12D)1Sco/? Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000005483	Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*	/ complex / reaction
ENSMUSG00000005469	P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*	/ reaction
ENSMUSG00000005034	P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*	/ reaction
ENSMUSG00000053436	Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*	/ complex
ENSMUSG00000018932	Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*	/ reaction
ENSMUSG00000020623	Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*	/ reaction
ENSMUSG00000053137	Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*	/ complex
ENSMUSG00000048756	Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*	/ reaction
ENSMUSG00000045664	Q8JZX9 / Cdc42ep2 / Cdc42 effector protein 2 / O14613*	/ reaction
ENSMUSG00000036533	Q9CQC5 / Cdc42ep3 / Cdc42 effector protein 3 / Q9UKI2*	/ reaction
ENSMUSG00000044167	Foxo1 / Q9R1E0 / Forkhead box protein O1 / Q12778* / forkhead box O1*	/ reaction
ENSMUSG00000004951	Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*	/ reaction
ENSMUSG00000059552	Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*	/ reaction
ENSMUSG00000063838	Q9Z0X0 / 1700027J19Rik / CDC42 effector protein (Rho GTPase binding) 5 / Q6NZY7* / CDC42EP5* / CDC42 effector protein 5*	/ reaction
ENSMUSG00000042688	Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*	/ complex / reaction
ENSMUSG00000061751	Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*	/ complex / reaction
ENSMUSG00000024558	Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*	/ reaction / complex
ENSMUSG00000001833	Sept7 / septin-7 isoform 2 / Q16181* / septin 7*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr