ENSMUSG00000004951


Mus musculus

Features
Gene ID: ENSMUSG00000004951
  
Biological name :Hspb1
  
Synonyms : Heat shock protein beta-1 / Hspb1 / P14602
  
Possible biological names infered from orthology : heat shock protein family B (small) member 1 / P04792
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 135887919
Gene end: 135889563
  
Corresponding Affymetrix probe sets: 10408928 (MoGene1.0st)   10526410 (MoGene1.0st)   1422943_a_at (Mouse Genome 430 2.0 Array)   1425964_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106785
Ensembl peptide - ENSMUSP00000005077
NCBI entrez gene - 15507     See in Manteia.
MGI - MGI:96240
RefSeq - NM_013560
RefSeq Peptide - NP_038588
swissprot - D3YZ06
swissprot - P14602
swissprot - Q545F4
Ensembl - ENSMUSG00000004951
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspb1ENSDARG00000041065Danio rerio
 HSPB1ENSGALG00000001926Gallus gallus
 HSPB1ENSG00000106211Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cryab / P23927 / Alpha-crystallin B chain / P02511* / crystallin alpha B*ENSMUSG0000003206036
Hspb8 / Q9JK92 / Heat shock protein beta-8 / Q9UJY1* / heat shock protein family B (small) member 8*ENSMUSG0000004154834
Cryaa / P24622 / Alpha-crystallin A chain / P02489* / CRYAA2* / crystallin alpha A* / crystallin alpha A2*ENSMUSG0000002404133
Hspb6 / Q5EBG6 / Heat shock protein beta-6 / O14558* / heat shock protein family B (small) member 6*ENSMUSG0000003685432
Hspb2 / Q99PR8 / Heat shock protein beta-2 / Q16082* / HSPB2-C11orf52* / HSPB2-C11orf52 readthrough (NMD candidate)* / heat shock protein family B (small) member 2*ENSMUSG0000003808629
Hspb3 / Q9QZ57 / Heat shock protein beta-3 / Q12988* / heat shock protein family B (small) member 3*ENSMUSG0000005145622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001436  Alpha crystallin/Heat shock protein
 IPR002068  Alpha crystallin/Hsp20 domain
 IPR008978  HSP20-like chaperone
 IPR031107  Small heat shock protein HSP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0006986 response to unfolded protein NAS
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0099641 anterograde axonal protein transport IEA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IDA
 cellular_componentGO:0000502 proteasome complex ISS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0043292 contractile fiber IDA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0008426 protein kinase C inhibitor activity IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0044183 protein binding involved in protein folding IEA


Pathways (from Reactome)
Pathway description
VEGFA-VEGFR2 Pathway
AUF1 (hnRNP D0) binds and destabilizes mRNA
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex
 ENSMUSG00000004951 Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*  / -
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction






 

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