ENSMUSG00000041548


Mus musculus

Features
Gene ID: ENSMUSG00000041548
  
Biological name :Hspb8
  
Synonyms : Heat shock protein beta-8 / Hspb8 / Q9JK92
  
Possible biological names infered from orthology : heat shock protein family B (small) member 8 / Q9UJY1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 116408491
Gene end: 116422864
  
Corresponding Affymetrix probe sets: 10533050 (MoGene1.0st)   1417013_at (Mouse Genome 430 2.0 Array)   1417014_at (Mouse Genome 430 2.0 Array)   1456434_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037007
NCBI entrez gene - 80888     See in Manteia.
MGI - MGI:2135756
RefSeq - NM_030704
RefSeq Peptide - NP_109629
swissprot - Q9JK92
Ensembl - ENSMUSG00000041548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspb8ENSDARG00000058365Danio rerio
 HSPB8ENSGALG00000007383Gallus gallus
 HSPB8ENSG00000152137Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*ENSMUSG0000000495137
Cryab / P23927 / Alpha-crystallin B chain / P02511* / crystallin alpha B*ENSMUSG0000003206028
Hspb6 / Q5EBG6 / Heat shock protein beta-6 / O14558* / heat shock protein family B (small) member 6*ENSMUSG0000003685424
Hspb2 / Q99PR8 / Heat shock protein beta-2 / Q16082* / HSPB2-C11orf52* / HSPB2-C11orf52 readthrough (NMD candidate)* / heat shock protein family B (small) member 2*ENSMUSG0000003808623
Cryaa / P24622 / Alpha-crystallin A chain / P02489* / CRYAA2* / crystallin alpha A* / crystallin alpha A2*ENSMUSG0000002404122
Hspb3 / Q9QZ57 / Heat shock protein beta-3 / Q12988* / heat shock protein family B (small) member 3*ENSMUSG0000005145615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001436  Alpha crystallin/Heat shock protein
 IPR002068  Alpha crystallin/Hsp20 domain
 IPR008978  HSP20-like chaperone
 IPR031107  Small heat shock protein HSP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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