ENSMUSG00000024041


Mus musculus

Features
Gene ID: ENSMUSG00000024041
  
Biological name :Cryaa
  
Synonyms : Alpha-crystallin A chain / Cryaa / P24622
  
Possible biological names infered from orthology : CRYAA2 / crystallin alpha A / crystallin alpha A2 / P02489
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 31677933
Gene end: 31681724
  
Corresponding Affymetrix probe sets: 10443830 (MoGene1.0st)   1452486_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019192
Ensembl peptide - ENSMUSP00000154747
NCBI entrez gene - 12954     See in Manteia.
MGI - MGI:88515
RefSeq - NM_013501
RefSeq - NM_001278569
RefSeq - NM_001278570
RefSeq Peptide - NP_001265498
RefSeq Peptide - NP_001265499
RefSeq Peptide - NP_038529
swissprot - P24622
swissprot - Q546L9
swissprot - Q569M7
Ensembl - ENSMUSG00000024041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cryaaENSDARG00000053502Danio rerio
 CRYAAENSGALG00000016199Gallus gallus
 CRYAAENSG00000160202Homo sapiens
 CRYAA2ENSG00000276076Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cryab / P23927 / Alpha-crystallin B chain / P02511* / crystallin alpha B*ENSMUSG0000003206047
Hspb6 / Q5EBG6 / Heat shock protein beta-6 / O14558* / heat shock protein family B (small) member 6*ENSMUSG0000003685437
Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*ENSMUSG0000000495135
Hspb2 / Q99PR8 / Heat shock protein beta-2 / Q16082* / HSPB2-C11orf52* / HSPB2-C11orf52 readthrough (NMD candidate)* / heat shock protein family B (small) member 2*ENSMUSG0000003808626
Hspb8 / Q9JK92 / Heat shock protein beta-8 / Q9UJY1* / heat shock protein family B (small) member 8*ENSMUSG0000004154822
Hspb3 / Q9QZ57 / Heat shock protein beta-3 / Q12988* / heat shock protein family B (small) member 3*ENSMUSG0000005145618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001436  Alpha crystallin/Heat shock protein
 IPR002068  Alpha crystallin/Hsp20 domain
 IPR003090  Alpha-crystallin, N-terminal
 IPR008978  HSP20-like chaperone
 IPR012274  Alpha-crystallin, subunit A
 IPR031107  Small heat shock protein HSP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007017 microtubule-based process IMP
 biological_processGO:0007021 tubulin complex assembly IMP
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IGI
 biological_processGO:0070141 response to UV-A IMP
 biological_processGO:0070309 lens fiber cell morphogenesis IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0005212 structural constituent of eye lens TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: CryaaAey7/CryaaAey7
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: Cryaa2J/Cryaa2J
Genetic Background: involves: BALB/c * FVB/N

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

Allelic Composition: CryaaAey7/CryaaAey7
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: Cryaa2J/Cryaa2J,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

Allelic Composition: CryaaL1N/CryaaL1N,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Cryaatm1.1Ady/Cryaa+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: CryaaAey7/CryaaAey7
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: CryaaL1N/Cryaa+
Genetic Background: involves: C3H/HeN * C57BL/6J

Allelic Composition: Cryaa2J/Cryaa2J
Genetic Background: involves: BALB/c * FVB/N

Allelic Composition: Cryaatm1.1Ady/Cryaa+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cryaatm1Ady/Cryaatm1Ady
Genetic Background: involves: 129

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: CryaaL1N/CryaaL1N
Genetic Background: involves: C3H/HeN * C57BL/6J

Allelic Composition: CryaaL1N/Cryaa+
Genetic Background: involves: C3H/HeN * C57BL/6J

Allelic Composition: Cryaa2J/Cryaa2J
Genetic Background: involves: BALB/c * FVB/N

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

Allelic Composition: Cryaatm1Ady/Cryaatm1Ady
Genetic Background: involves: 129

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0003236 abnormal lens capsule morphology "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Cryaa2J/Cryaa2J,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Cryaa2J/Cryaa2J,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

 MP:0008794 increased lens epithelium apopotosis "increase in the number of lens epithelial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Cryaatm1Wawr/Cryaatm1Wawr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

 MP:0008796 increased lens fiber apoptosis "increase in the number of lens fibers cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryaatm1Ady/Cryaatm1Ady
Genetic Background: involves: 129

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: CryaaL1N/CryaaL1N
Genetic Background: involves: C3H/HeN * C57BL/6J

Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cryaatm1Ady/Cryaa+
Genetic Background: involves: 129

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
Show

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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