ENSMUSG00000032060


Mus musculus

Features
Gene ID: ENSMUSG00000032060
  
Biological name :Cryab
  
Synonyms : Alpha-crystallin B chain / Cryab / P23927
  
Possible biological names infered from orthology : crystallin alpha B / P02511
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 50751325
Gene end: 50756636
  
Corresponding Affymetrix probe sets: 10585214 (MoGene1.0st)   1416455_a_at (Mouse Genome 430 2.0 Array)   1434369_a_at (Mouse Genome 430 2.0 Array)   1435837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149454
Ensembl peptide - ENSMUSP00000149803
Ensembl peptide - ENSMUSP00000150669
Ensembl peptide - ENSMUSP00000034562
Ensembl peptide - ENSMUSP00000149759
NCBI entrez gene - 12955     See in Manteia.
MGI - MGI:88516
RefSeq - XM_006509970
RefSeq - NM_001289782
RefSeq - NM_001289784
RefSeq - NM_001289785
RefSeq - NM_009964
RefSeq Peptide - NP_001276711
RefSeq Peptide - NP_001276713
RefSeq Peptide - NP_001276714
RefSeq Peptide - NP_034094
swissprot - P23927
swissprot - Q52L78
swissprot - A0A1L1SRG5
Ensembl - ENSMUSG00000032060
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cryabbENSDARG00000101380Danio rerio
 CRYABENSGALG00000007945Gallus gallus
 CRYABENSG00000109846Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cryaa / P24622 / Alpha-crystallin A chain / P02489* / CRYAA2* / crystallin alpha A* / crystallin alpha A2*ENSMUSG0000002404153
Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*ENSMUSG0000000495143
Hspb6 / Q5EBG6 / Heat shock protein beta-6 / O14558* / heat shock protein family B (small) member 6*ENSMUSG0000003685443
Hspb2 / Q99PR8 / Heat shock protein beta-2 / Q16082* / HSPB2-C11orf52* / HSPB2-C11orf52 readthrough (NMD candidate)* / heat shock protein family B (small) member 2*ENSMUSG0000003808633
Hspb8 / Q9JK92 / Heat shock protein beta-8 / Q9UJY1* / heat shock protein family B (small) member 8*ENSMUSG0000004154831
Hspb3 / Q9QZ57 / Heat shock protein beta-3 / Q12988* / heat shock protein family B (small) member 3*ENSMUSG0000005145621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001436  Alpha crystallin/Heat shock protein
 IPR002068  Alpha crystallin/Hsp20 domain
 IPR003090  Alpha-crystallin, N-terminal
 IPR008978  HSP20-like chaperone
 IPR031107  Small heat shock protein HSP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0002088 lens development in camera-type eye IGI
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0007021 tubulin complex assembly IMP
 biological_processGO:0007517 muscle organ development IGI
 biological_processGO:0007568 aging IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010941 regulation of cell death ISO
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0031109 microtubule polymerization or depolymerization IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032387 negative regulation of intracellular transport ISO
 biological_processGO:0032463 negative regulation of protein homooligomerization ISO
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IGI
 biological_processGO:0071480 cellular response to gamma radiation ISO
 biological_processGO:1905907 negative regulation of amyloid fibril formation ISO
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0031674 I band IEA
 cellular_componentGO:0032432 actin filament bundle IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043292 contractile fiber IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 cellular_componentGO:0097512 cardiac myofibril IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005212 structural constituent of eye lens TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding ISO


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
Show

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr2tm1.1Wex/Ryr2tm1.1Wex
Genetic Background: B6.129S7-Ryr2tm1.1Wex

Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cryabtm1.1Ady/Cryab+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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