ENSMUSG00000029580


Mus musculus

Features
Gene ID: ENSMUSG00000029580
  
Biological name :Actb
  
Synonyms : Actb / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / P60710
  
Possible biological names infered from orthology : actin beta / P0CG39 / P60709 / POTE ankyrin domain family member J / POTEJ
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 142903115
Gene end: 142906754
  
Corresponding Affymetrix probe sets: 10535381 (MoGene1.0st)   1419734_at (Mouse Genome 430 2.0 Array)   1436722_a_at (Mouse Genome 430 2.0 Array)   AFFX-b-ActinMur/M12481_3_at (Mouse Genome 430 2.0 Array)   AFFX-b-ActinMur/M12481_5_at (Mouse Genome 430 2.0 Array)   AFFX-b-ActinMur/M12481_M_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098066
Ensembl peptide - ENSMUSP00000132135
Ensembl peptide - ENSMUSP00000130611
Ensembl peptide - ENSMUSP00000127663
Ensembl peptide - ENSMUSP00000101823
NCBI entrez gene - 11461     See in Manteia.
MGI - MGI:87904
RefSeq - NM_007393
RefSeq Peptide - NP_031419
swissprot - E9Q1F2
swissprot - B2RRX1
swissprot - E9Q606
swissprot - P60710
swissprot - E9Q5F4
swissprot - E9Q2D1
Ensembl - ENSMUSG00000029580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actb1ENSDARG00000037746Danio rerio
 actb2ENSDARG00000037870Danio rerio
 ACTBENSGALG00000009621Gallus gallus
 ACTG1ENSGALG00000001381Gallus gallus
 ACTBENSG00000075624Homo sapiens
 POTEJENSG00000222038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*ENSMUSG0000006282599
Acta2 / P62737 / Actin, aortic smooth muscle Actin, aortic smooth muscle, intermediate form / P62736* / actin, alpha 2, smooth muscle, aorta*ENSMUSG0000003578394
Actc1 / P68033 / Actin, alpha cardiac muscle 1 / P68032*ENSMUSG0000006861494
Actg2 / P63268 / Actin, gamma-enteric smooth muscle / P63267* / actin, gamma 2, smooth muscle, enteric*ENSMUSG0000005943093
Acta1 / P68134 / Actin, alpha skeletal muscle / P68133* / actin, alpha 1, skeletal muscle*ENSMUSG0000003197293
Actbl2 / Q8BFZ3 / Beta-actin-like protein 2 / Q562R1* / actin, beta like 2*ENSMUSG0000005519493
Actr1b / Q8R5C5 / Beta-centractin / P42025* / ARP1 actin related protein 1 homolog B*ENSMUSG0000003735154
Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*ENSMUSG0000002522853
Actrt2 / Q9D9L5 / Actin-related protein T2 / Q8TDY3*ENSMUSG0000005127650
Gm498ENSMUSG0000003108549
Actrt1 / Q9D9J3 / Actin-related protein T1 / Q8TDG2*ENSMUSG0000004661548
Actrt3 / Q8BXF8 / Actin-related protein T3 / Q9BYD9*ENSMUSG0000003773746
Actl7a / Q9QY84 / actin-like 7a / Q9Y615*ENSMUSG0000007097944
Actl7b / Q9QY83 / actin-like 7b / Q9Y614*ENSMUSG0000007098044
Actl9 / Q8CG27 / Actin-like protein 9 / Q8TC94* / actin like 9*ENSMUSG0000009251941
Actl11 / actin-like 11ENSMUSG0000006636839


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR020902  Actin/actin-like conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0098974 postsynaptic actin cytoskeleton organization ISO
 biological_processGO:1904030 negative regulation of cyclin-dependent protein kinase activity IC
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0097433 dense body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019894 kinesin binding ISO
 molecular_functionGO:0030957 Tat protein binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0050998 nitric-oxide synthase binding ISO
 molecular_functionGO:0098973 structural constituent of postsynaptic actin cytoskeleton ISO


Pathways (from Reactome)
Pathway description
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
Adherens junctions interactions
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
B-WICH complex positively regulates rRNA expression
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
MAP2K and MAPK activation
UCH proteinases
DNA Damage Recognition in GG-NER
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Actbtm1Npa/Actbtm1Npa
Genetic Background: involves: BALB/cJ

Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Actbtm1(PyVT)Arge/Actb+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Actbtm1(PyVT)Arge/Actb+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Camk2a-cre)#Szi/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Hsp70-1-cre)6Arge/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Actbtm1(PyVT)Arge/Actb+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Camk2a-cre)#Szi/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Hsp70-1-cre)6Arge/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2.1Flv/Rad50tm2.1Flv
Genetic Background: B6.129S6-Rad50tm2.1Flv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rad50tm2.1Flv/Rad50tm2.1Flv
Genetic Background: B6.129S6-Rad50tm2.1Flv

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002683 delayed fertility "ability to produce live offspring occuring at a later than expected age" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002997 enlarged seminal gland "increased size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Actbtm1.1Erv/Actbtm1.1Erv,Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(Atoh1-cre)1Bfri/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * FVB/N

 MP:0004524 short cochlear hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Actbtm1(PyVT)Arge/Actb+,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Camk2a-cre)#Szi/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Hsp70-1-cre)6Arge/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Actbtm4(cre/ERT2)Npa/Actb+,Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0009342 enlarged gall bladder "increased size of the gall bladder, the organ that serves as a storage reservoir for bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

Allelic Composition: Actbtm1Npa/Actbtm1Npa
Genetic Background: involves: BALB/cJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction / complex
 ENSMUSG00000004951 Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*  / complex
 ENSMUSG00000008859 Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*  / reaction / complex
 ENSMUSG00000021262 Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*  / complex / reaction
 ENSMUSG00000017774 Myo1c / Q9WTI7 / Unconventional myosin-Ic / O00159* / myosin IC*  / reaction / complex
 ENSMUSG00000028068 Iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*  / complex / reaction
 ENSMUSG00000021676 Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2 / Q13576* / IQ motif containing GTPase activating protein 2*  / reaction / complex
 ENSMUSG00000052397 Ezr / Ezrin / P26040 / P15311*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000023008 Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*  / reaction / complex
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / - / reaction / complex
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex / -
 ENSMUSG00000033196 Myh2 / myosin heavy chain 2 / Q9UKX2*  / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / reaction / complex
 ENSMUSG00000022272 Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*  / complex / reaction
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex
 ENSMUSG00000031543 Ank1 / Q02357 / Ankyrin-1 / P16157*  / complex / reaction
 ENSMUSG00000025372 Baiap2 / Q8BKX1 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q9UQB8* / BAI1 associated protein 2*  / reaction / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / complex / reaction
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000034593 Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*  / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex / reaction
 ENSMUSG00000032826 Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*  / reaction / complex
 ENSMUSG00000026425 Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...  / reaction / complex
 ENSMUSG00000068699 Flnc / Q8VHX6 / Filamin-C / Q14315*  / complex / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex / reaction
 ENSMUSG00000006219 Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*  / reaction / complex
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / complex
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / reaction / complex
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / reaction / complex






 

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