ENSMUSG00000021676


Mus musculus

Features
Gene ID: ENSMUSG00000021676
  
Biological name :Iqgap2
  
Synonyms : Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2
  
Possible biological names infered from orthology : IQ motif containing GTPase activating protein 2 / Q13576
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 95627177
Gene end: 95891922
  
Corresponding Affymetrix probe sets: 10411235 (MoGene1.0st)   1433885_at (Mouse Genome 430 2.0 Array)   1459894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067685
NCBI entrez gene - 544963     See in Manteia.
MGI - MGI:2449975
RefSeq - NM_027711
RefSeq - XM_011244681
RefSeq Peptide - NP_081987
swissprot - Q3UQ44
Ensembl - ENSMUSG00000021676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap2ENSDARG00000060010Danio rerio
 IQGAP2ENSGALG00000014978Gallus gallus
 IQGAP2ENSG00000145703Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*ENSMUSG0000003053660
Iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*ENSMUSG0000002806849


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031941 filamentous actin IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0071933 Arp2/3 complex binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Iqgap1tm1Aber/Iqgap1tm1Aber,Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic Background: involves: 129S4/SvJae

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Iqgap1tm1Aber/Iqgap1tm1Aber,Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic Background: involves: 129S4/SvJae

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021676 Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2 / Q13576* / IQ motif containing GTPase activating protein 2*  / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction






 

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