ENSDARG00000060010


Danio rerio

Features
Gene ID: ENSDARG00000060010
  
Biological name :iqgap2
  
Synonyms : iqgap2 / IQ motif containing GTPase activating protein 2
  
Possible biological names infered from orthology : Q13576 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 46077710
Gene end: 46196708
  
Corresponding Affymetrix probe sets: Dr.7282.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000078504
Ensembl peptide - ENSDARP00000122218
NCBI entrez gene - 563030     See in Manteia.
RefSeq - NM_001128340
RefSeq Peptide - NP_001121812
swissprot - F1QAC1
swissprot - A2CE93
ZFIN ID - ZDB-GENE-030131-2878
Ensembl - ENSDARG00000060010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IQGAP2ENSGALG00000014978Gallus gallus
 IQGAP2ENSG00000145703Homo sapiens
 Iqgap2ENSMUSG00000021676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
iqgap1 / IQ motif containing GTPase activating protein 1 / P46940*ENSDARG0000007888859
iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*ENSDARG0000009865051


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus increased size , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
Show

 ZFA:0005283 renal capsular space renal capsular space increased size , abnormal
Show

 ZFA:0005285 glomerular basement membrane glomerular basement membrane podocyte foot morphology , abnormal
glomerular basement membrane podocyte foot increased width , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000060010 iqgap2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *  / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / reaction / complex
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / complex / reaction
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex / reaction






 

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