ENSG00000145703


Homo sapiens

Features
Gene ID: ENSG00000145703
  
Biological name :IQGAP2
  
Synonyms : IQGAP2 / IQ motif containing GTPase activating protein 2 / Q13576
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.3
Gene start: 76403249
Gene end: 76708132
  
Corresponding Affymetrix probe sets: 203474_at (Human Genome U133 Plus 2.0 Array)   241723_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421319
Ensembl peptide - ENSP00000442313
Ensembl peptide - ENSP00000426027
Ensembl peptide - ENSP00000425941
Ensembl peptide - ENSP00000425351
Ensembl peptide - ENSP00000423672
Ensembl peptide - ENSP00000423258
Ensembl peptide - ENSP00000422661
Ensembl peptide - ENSP00000274364
Ensembl peptide - ENSP00000379535
Ensembl peptide - ENSP00000421097
NCBI entrez gene - 10788     See in Manteia.
OMIM - 605401
RefSeq - XM_017008960
RefSeq - NM_001285460
RefSeq - NM_001285461
RefSeq - NM_001285462
RefSeq - NM_006633
RefSeq - XM_005248410
RefSeq - XM_005248414
RefSeq - XM_011543108
RefSeq Peptide - NP_006624
RefSeq Peptide - NP_001272389
RefSeq Peptide - NP_001272390
RefSeq Peptide - NP_001272391
swissprot - D6RDK8
swissprot - D6R999
swissprot - D6R939
swissprot - E7EWC2
swissprot - F5H7S7
swissprot - H0YA28
swissprot - Q13576
swissprot - E9PDT6
swissprot - D6RGC6
Ensembl - ENSG00000145703
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap2ENSDARG00000060010Danio rerio
 IQGAP2ENSGALG00000014978Gallus gallus
 Iqgap2ENSMUSG00000021676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1ENSG0000014057561
IQGAP3 / Q86VI3 / IQ motif containing GTPase activating protein 3ENSG0000018385652


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IDA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005095 GTPase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0017048 Rho GTPase binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA
 molecular_functionGO:0051015 actin filament binding IDA
 molecular_functionGO:0071933 Arp2/3 complex binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145703 IQGAP2 / Q13576 / IQ motif containing GTPase activating protein 2  / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex






 

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