ENSG00000140575


Homo sapiens

Features
Gene ID: ENSG00000140575
  
Biological name :IQGAP1
  
Synonyms : IQGAP1 / IQ motif containing GTPase activating protein 1 / P46940
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.1
Gene start: 90388218
Gene end: 90502243
  
Corresponding Affymetrix probe sets: 200791_s_at (Human Genome U133 Plus 2.0 Array)   210840_s_at (Human Genome U133 Plus 2.0 Array)   213446_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484647
Ensembl peptide - ENSP00000268182
Ensembl peptide - ENSP00000488618
Ensembl peptide - ENSP00000452723
Ensembl peptide - ENSP00000480393
Ensembl peptide - ENSP00000453181
NCBI entrez gene - 8826     See in Manteia.
OMIM - 603379
RefSeq - NM_003870
RefSeq Peptide - NP_003861
swissprot - A0A087WWP1
swissprot - A0A024RC65
swissprot - H0YKA5
swissprot - H0YLE8
swissprot - A0A0J9YXZ5
swissprot - P46940
swissprot - A0A087X225
Ensembl - ENSG00000140575
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap1ENSDARG00000078888Danio rerio
 IQGAP1ENSGALG00000030162Gallus gallus
 Iqgap1ENSMUSG00000030536Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IQGAP3 / Q86VI3 / IQ motif containing GTPase activating protein 3ENSG0000018385658
IQGAP2 / Q13576 / IQ motif containing GTPase activating protein 2ENSG0000014570358


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035305 negative regulation of dephosphorylation IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development ISS
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:1903829 positive regulation of cellular protein localization IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1990138 neuron projection extension IMP
 biological_processGO:1990776 response to angiotensin IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0005884 actin filament TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015629 actin cytoskeleton ISS
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0036057 slit diaphragm ISS
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005095 GTPase inhibitor activity TAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IDA
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Nephrin family interactions
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
RHO GTPases activate IQGAPs
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction / complex
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex / reaction
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / complex
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000130779 CLIP1 / P30622 / CAP-Gly domain containing linker protein 1  / reaction / complex
 ENSG00000133895 MEN1 / O00255 / menin 1  / reaction / complex
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / complex / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000183853 Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / complex
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex






 

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