ENSG00000142875


Homo sapiens

Features
Gene ID: ENSG00000142875
  
Biological name :PRKACB
  
Synonyms : P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.1
Gene start: 84078062
Gene end: 84238498
  
Corresponding Affymetrix probe sets: 202741_at (Human Genome U133 Plus 2.0 Array)   202742_s_at (Human Genome U133 Plus 2.0 Array)   235780_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378314
Ensembl peptide - ENSP00000359723
Ensembl peptide - ENSP00000378315
Ensembl peptide - ENSP00000481980
Ensembl peptide - ENSP00000479722
Ensembl peptide - ENSP00000479339
Ensembl peptide - ENSP00000401252
Ensembl peptide - ENSP00000399326
Ensembl peptide - ENSP00000397175
Ensembl peptide - ENSP00000393654
Ensembl peptide - ENSP00000392275
Ensembl peptide - ENSP00000390906
Ensembl peptide - ENSP00000359714
Ensembl peptide - ENSP00000359716
Ensembl peptide - ENSP00000359718
Ensembl peptide - ENSP00000359719
Ensembl peptide - ENSP00000359722
NCBI entrez gene - 5567     See in Manteia.
OMIM - 176892
RefSeq - XM_017001720
RefSeq - NM_182948
RefSeq - NM_207578
RefSeq - XM_005271015
RefSeq - XM_005271016
RefSeq - XM_005271017
RefSeq - XM_005271018
RefSeq - XM_005271019
RefSeq - XM_005271020
RefSeq - XM_006710758
RefSeq - XM_017001706
RefSeq - XM_017001707
RefSeq - XM_017001708
RefSeq - XM_017001709
RefSeq - XM_017001710
RefSeq - XM_017001711
RefSeq - XM_017001712
RefSeq - XM_017001713
RefSeq - XM_017001714
RefSeq - XM_017001715
RefSeq - XM_017001716
RefSeq - XM_017001717
RefSeq - XM_017001718
RefSeq - XM_017001719
RefSeq - NM_001242857
RefSeq - NM_001242858
RefSeq - NM_001242859
RefSeq - NM_001242860
RefSeq - NM_001242861
RefSeq - NM_001242862
RefSeq - NM_001300915
RefSeq - NM_001300916
RefSeq - NM_001300917
RefSeq - NM_002731
RefSeq Peptide - NP_001229787
RefSeq Peptide - NP_001229788
RefSeq Peptide - NP_001229789
RefSeq Peptide - NP_001229790
RefSeq Peptide - NP_001229791
RefSeq Peptide - NP_001287844
RefSeq Peptide - NP_001287845
RefSeq Peptide - NP_001287846
RefSeq Peptide - NP_002722
RefSeq Peptide - NP_891993
RefSeq Peptide - NP_997461
RefSeq Peptide - NP_001229786
swissprot - B1APG3
swissprot - B1APG2
swissprot - B1APG1
swissprot - B1APG0
swissprot - B1APF9
swissprot - B1APF8
swissprot - B1APF7
swissprot - A0A0A0MS54
swissprot - B2RB89
swissprot - P22694
swissprot - A0A087WVC4
Ensembl - ENSG00000142875
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkacbbENSDARG00000059125Danio rerio
 PRKACBENSGALG00000028530Gallus gallus
 P68181ENSMUSG00000005034Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alphaENSG0000007206280
P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gammaENSG0000016505968
PRKX / P51817 / protein kinase, X-linkedENSG0000018394343
PRKG1 / Q13976 / protein kinase, cGMP-dependent, type IENSG0000018553240
PRKG2 / Q13237 / protein kinase, cGMP-dependent, type IIENSG0000013866939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0034380 high-density lipoprotein particle assembly TAS
 biological_processGO:0051447 negative regulation of meiotic cell cycle IEA
 biological_processGO:0070613 regulation of protein processing IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:0097338 response to clozapine IEA
 biological_processGO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097546 ciliary base TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004691 cAMP-dependent protein kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA


Pathways (from Reactome)
Pathway description
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB phosphorylation through the activation of Adenylate Cyclase
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog off state
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
Glycolysis
RET signaling
HDL assembly
ROBO receptors bind AKAP5
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108599 AKAP10 / O43572 / A-kinase anchoring protein 10  / complex / reaction
 ENSG00000121057 AKAP1 / Q92667 / A-kinase anchoring protein 1  / complex / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / complex
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / reaction / complex
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / complex
 ENSG00000107882 SUFU / Q9UMX1 / SUFU negative regulator of hedgehog signaling  / reaction
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex
 ENSG00000167580 AQP2 / P41181 / aquaporin 2  / reaction
 ENSG00000009950 MLXIPL / Q9NP71 / MLX interacting protein like  / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / complex / reaction
 ENSG00000184588 PDE4B / Q07343 / phosphodiesterase 4B  / reaction
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex
 ENSG00000111087 GLI1 / P08151 / GLI family zinc finger 1  / reaction
 ENSG00000132359 Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2  / reaction
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000165029 ABCA1 / O95477 / ATP binding cassette subfamily A member 1  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000158571 P16118 / PFKFB1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1  / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000079435 LIPE / Q05469 / lipase E, hormone sensitive type  / reaction
 ENSG00000166819 PLIN1 / O60240 / perilipin 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr