ENSG00000188191


Homo sapiens

Features
Gene ID: ENSG00000188191
  
Biological name :PRKAR1B
  
Synonyms : P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.3
Gene start: 549197
Gene end: 727650
  
Corresponding Affymetrix probe sets: 212555_at (Human Genome U133 Plus 2.0 Array)   212559_at (Human Genome U133 Plus 2.0 Array)   238183_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402648
Ensembl peptide - ENSP00000394633
Ensembl peptide - ENSP00000406670
Ensembl peptide - ENSP00000444487
Ensembl peptide - ENSP00000440449
Ensembl peptide - ENSP00000410414
Ensembl peptide - ENSP00000353415
Ensembl peptide - ENSP00000383569
Ensembl peptide - ENSP00000385349
Ensembl peptide - ENSP00000385749
NCBI entrez gene - 5575     See in Manteia.
OMIM - 176911
RefSeq - XM_017012434
RefSeq - NM_001164758
RefSeq - NM_001164759
RefSeq - NM_001164760
RefSeq - NM_001164761
RefSeq - NM_001164762
RefSeq - NM_002735
RefSeq - XM_011515446
RefSeq - XM_017012433
RefSeq Peptide - NP_001158230
RefSeq Peptide - NP_001158231
RefSeq Peptide - NP_001158232
RefSeq Peptide - NP_001158233
RefSeq Peptide - NP_001158234
RefSeq Peptide - NP_002726
swissprot - C9J4C2
swissprot - C9IZL8
swissprot - C9JSK5
swissprot - C9JR00
swissprot - P31321
swissprot - H7BYW5
Ensembl - ENSG00000188191
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar1bENSDARG00000103800Danio rerio
 PRKAR1BENSGALG00000003675Gallus gallus
 P12849ENSMUSG00000025855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alphaENSG0000010894681
P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alphaENSG0000011430238
P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit betaENSG0000000524937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097546 ciliary base TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity NAS
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000719 Inappropriate behavior 
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 HP:0000736 Short attention span "Reduced attention span characterized by distractibility and impulsivity but not necessarily satisfying the diagnostic criteria for attention deficit hyperactivity disorder." [HPO:curators]
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 HP:0000739 Anxiety 
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 HP:0000741 Apathy 
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 HP:0001300 Parkinsonism 
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 HP:0002067 Bradykinesia "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." [HPO:curators]
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 HP:0002145 Frontotemporal dementia 
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 HP:0002172 Postural instability 
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 HP:0002333 Motor deterioration 
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 HP:0002354 Memory impairment 
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 HP:0002463 Language impairment 
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 HP:0002506 Diffuse cerebral atrophy 
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 HP:0002527 Falls 
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 HP:0003552 Muscle stiffness 
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 HP:0006892 Cerebral atrophy, frontotemporal, progressive 
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 HP:0007311 Short stepped shuffling gait 
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 HP:0010794 Impaired visuospatial constructive cognition "Reduced ability affecting mainly the visuospatial cognition which may be tested using pattern construction (for example by Differential Ability Scales (DAS), which test a person s strengths and weaknesses across a range of intellectual abilities). Impaired visuospatial constructive cognition is one of the characteristic featrues of most patients with Willimas-Beuren Syndrome." [HPO:sdoelken]
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 HP:0012757 Abnormal neuron morphology "A structural anomaly of a neuron." [KI:phemming]
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 HP:0030216 Inertia "Reduction of goal-directed behaviors linked to the impairment in frontal executive functions (planning of an action for example)." [ICM:PCaroppo]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108599 AKAP10 / O43572 / A-kinase anchoring protein 10  / reaction / complex
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000121057 AKAP1 / Q92667 / A-kinase anchoring protein 1  / reaction / complex
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / complex
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / complex
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / complex
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex






 

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