ENSG00000005249


Homo sapiens

Features
Gene ID: ENSG00000005249
  
Biological name :PRKAR2B
  
Synonyms : P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q22.3
Gene start: 107044649
Gene end: 107161811
  
Corresponding Affymetrix probe sets: 203680_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265717
NCBI entrez gene - 5577     See in Manteia.
OMIM - 176912
RefSeq - XM_011516398
RefSeq - NM_002736
RefSeq Peptide - NP_002727
swissprot - P31323
swissprot - A0A024R712
Ensembl - ENSG00000005249
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKAR2BENSDARG00000036446Danio rerio
 PRKAR2BENSGALG00000008060Gallus gallus
 P31324ENSMUSG00000002997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alphaENSG0000011430266
P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit betaENSG0000018819134
P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alphaENSG0000010894633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007612 learning IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:0097332 response to antipsychotic drug IEA
 biological_processGO:0097338 response to clozapine IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0043198 dendritic shaft ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097546 ciliary base TAS
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108599 AKAP10 / O43572 / A-kinase anchoring protein 10  / reaction / complex
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / complex
 ENSG00000121057 AKAP1 / Q92667 / A-kinase anchoring protein 1  / complex / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / complex
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / complex
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex






 

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