ENSMUSG00000002997


Mus musculus

Features
Gene ID: ENSMUSG00000002997
  
Biological name :Prkar2b
  
Synonyms : P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta
  
Possible biological names infered from orthology : P31323 / protein kinase cAMP-dependent type II regulatory subunit beta
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A3
Gene start: 31958476
Gene end: 32061296
  
Corresponding Affymetrix probe sets: 10399908 (MoGene1.0st)   1430640_a_at (Mouse Genome 430 2.0 Array)   1438664_at (Mouse Genome 430 2.0 Array)   1456475_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003079
Ensembl peptide - ENSMUSP00000039797
Ensembl peptide - ENSMUSP00000135290
NCBI entrez gene - 19088     See in Manteia.
MGI - MGI:97760
RefSeq - NM_011158
RefSeq - XM_006515014
RefSeq Peptide - NP_035288
swissprot - H3BK84
swissprot - P31324
Ensembl - ENSMUSG00000002997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKAR2BENSDARG00000036446Danio rerio
 PRKAR2BENSGALG00000008060Gallus gallus
 P31323ENSG00000005249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*ENSMUSG0000003260165
P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*ENSMUSG0000002585534
Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*ENSMUSG0000002061233


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0097332 response to antipsychotic drug IEA
 biological_processGO:0097338 response to clozapine IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097546 ciliary base IDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Drd2-cre)ER44Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Drd1tm1(cre)Rpa/Drd1+
Genetic Background: involves: C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm2Gsm/Prkar2b+
Genetic Background: involves: C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Ppp1r1b-cre)1Meeh/0
Genetic Background: involves: C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2b+
Genetic Background: involves: C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2b+
Genetic Background: involves: C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm2Gsm/Prkar2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm2Gsm/Prkar2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Ppp1r1b-cre)1Meeh/0
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Drd2-cre)ER44Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Ay/A,Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic Background: involves: C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Tg(Drd2-cre)ER44Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic Background: B6.Cg-Prkar2btm3Gsm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex
 ENSMUSG00000018428 Akap1 / O08715 / A-kinase anchor protein 1, mitochondrial / Q92667* / A-kinase anchoring protein 1*  / complex / reaction
 ENSMUSG00000047804 Akap10 / O88845 / A-kinase anchor protein 10, mitochondrial / O43572* / A-kinase anchoring protein 10*  / reaction / complex






 

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