ENSMUSG00000005034


Mus musculus

Features
Gene ID: ENSMUSG00000005034
  
Biological name :Prkacb
  
Synonyms : P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta
  
Possible biological names infered from orthology : P22694 / protein kinase cAMP-activated catalytic subunit beta
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 146729574
Gene end: 146812990
  
Corresponding Affymetrix probe sets: 10502732 (MoGene1.0st)   1420610_at (Mouse Genome 430 2.0 Array)   1420611_at (Mouse Genome 430 2.0 Array)   1457197_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099573
Ensembl peptide - ENSMUSP00000142490
Ensembl peptide - ENSMUSP00000005164
Ensembl peptide - ENSMUSP00000143303
Ensembl peptide - ENSMUSP00000101743
Ensembl peptide - ENSMUSP00000101744
NCBI entrez gene - 18749     See in Manteia.
MGI - MGI:97594
RefSeq - NM_001164200
RefSeq - NM_011100
RefSeq - NM_001164198
RefSeq - NM_001164199
RefSeq Peptide - NP_001157671
RefSeq Peptide - NP_035230
RefSeq Peptide - NP_001157670
RefSeq Peptide - NP_001157672
swissprot - P68181
swissprot - A0A0G2JFT9
swissprot - H6TMF5
Ensembl - ENSMUSG00000005034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkacbbENSDARG00000059125Danio rerio
 PRKACBENSGALG00000028530Gallus gallus
 P22694ENSG00000142875Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*ENSMUSG0000000546979
Prkx / Q922R0 / cAMP-dependent protein kinase catalytic subunit PRKX / P51817* / protein kinase, X-linked*ENSMUSG0000003572542
Prkg1 / P0C605 / protein kinase, cGMP-dependent, type I / Q13976*ENSMUSG0000005292040
Prkg2 / protein kinase, cGMP-dependent, type II / Q13237*ENSMUSG0000002933440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0051447 negative regulation of meiotic cell cycle IEA
 biological_processGO:0070613 regulation of protein processing IGI
 biological_processGO:0097338 response to clozapine IEA
 biological_processGO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097546 ciliary base IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004691 cAMP-dependent protein kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB phosphorylation through the activation of Adenylate Cyclase
GLI3 is processed to GLI3R by the proteasome
Hedgehog off state
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
RET signaling
HDL assembly
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000962 disorganized dorsal root ganglia "loss of segmentation pattern of DRGs; loss of regular spacing " [J:62022, J:62023]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex
 ENSMUSG00000025231 Sufu / Q9Z0P7 / SUFU negative regulator of hedgehog signaling / Q9UMX1*  / reaction
 ENSMUSG00000015243 Abca1 / P41233 / ATP-binding cassette, sub-family A (ABC1), member 1 / O95477* / ATP binding cassette subfamily A member 1*  / reaction
 ENSMUSG00000023013 Aqp2 / P56402 / Aquaporin-2 / P41181*  / reaction
 ENSMUSG00000048402 Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*  / reaction
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction
 ENSMUSG00000030546 Plin1 / Q8CGN5 / Perilipin-1 / O60240*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000021057 Akap5 / D3YVF0 / A-kinase anchor protein 5 / P24588* / A-kinase anchoring protein 5*  / reaction / complex
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSMUSG00000038807 Q5SVL6 / Rap1gap2 / Rap1 GTPase-activating protein 2 / Q684P5*  / reaction
 ENSMUSG00000018428 Akap1 / O08715 / A-kinase anchor protein 1, mitochondrial / Q92667* / A-kinase anchoring protein 1*  / reaction / complex
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex
 ENSMUSG00000047804 Akap10 / O88845 / A-kinase anchor protein 10, mitochondrial / O43572* / A-kinase anchoring protein 10*  / complex / reaction






 

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