ENSMUSG00000030546


Mus musculus

Features
Gene ID: ENSMUSG00000030546
  
Biological name :Plin1
  
Synonyms : Perilipin-1 / Plin1 / Q8CGN5
  
Possible biological names infered from orthology : O60240
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79720218
Gene end: 79732903
  
Corresponding Affymetrix probe sets: 10564795 (MoGene1.0st)   1436453_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145653
Ensembl peptide - ENSMUSP00000146198
Ensembl peptide - ENSMUSP00000146028
Ensembl peptide - ENSMUSP00000146003
Ensembl peptide - ENSMUSP00000145747
Ensembl peptide - ENSMUSP00000032762
Ensembl peptide - ENSMUSP00000136996
NCBI entrez gene - 103968     See in Manteia.
MGI - MGI:1890505
RefSeq - XM_011250776
RefSeq - NM_001113471
RefSeq - NM_175640
RefSeq Peptide - NP_001106942
RefSeq Peptide - NP_783571
swissprot - A0A0U1RQ08
swissprot - A0A0U1RPJ3
swissprot - A0A0U1RNP7
swissprot - A0A0U1RNY2
swissprot - Q8CGN5
Ensembl - ENSMUSG00000030546
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plin1ENSDARG00000054048Danio rerio
 PLIN1ENSGALG00000023395Gallus gallus
 PLIN1ENSG00000166819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plin5 / Q8BVZ1 / Perilipin-5 / Q00G26*ENSMUSG0000001130519
Plin3 / Q9DBG5 / Perilipin-3 / O60664*ENSMUSG0000002419719
Plin2 / P43883 / Perilipin-2 / Q99541*ENSMUSG0000002849418
Plin4 / O88492 / Perilipin-4 / Q96Q06*ENSMUSG0000000283112


Protein motifs (from Interpro)
Interpro ID Name
 IPR004279  Perilipin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005811 lipid droplet TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb,Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0003439 abnormal glycerol level "anomalous concentration of this molecule, the backbone of lipids, which is important for gluconeogenesis during starvation" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95278]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003457 abnormal circulating ketone body level "aberrant amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprdb/Leprdb,Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn1Gt(OST378842)Lex/Ptpn1Gt(OST378842)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008032 abnormal lipolysis "anomaly in the process of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009301 decreased parametrial fat pad weight 
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Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009421 increased gastrocnemius weight "increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plin1tm1Cdl/Plin1tm1Cdl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
Show

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014144 abnormal white adipose tissue mass "aberrant physical bulk or volume of white adipose tissue" [MGI:csmith]
Show

Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
Show

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSMUSG00000032540 Abhd5 / Q9DBL9 / abhydrolase domain containing 5 / Q8WTS1*  / complex






 

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