ENSMUSG00000032540


Mus musculus

Features
Gene ID: ENSMUSG00000032540
  
Biological name :Abhd5
  
Synonyms : Abhd5 / abhydrolase domain containing 5 / Q9DBL9
  
Possible biological names infered from orthology : Q8WTS1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 122351608
Gene end: 122381524
  
Corresponding Affymetrix probe sets: 10590452 (MoGene1.0st)   1417565_at (Mouse Genome 430 2.0 Array)   1417566_at (Mouse Genome 430 2.0 Array)   1447548_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122274
Ensembl peptide - ENSMUSP00000135538
Ensembl peptide - ENSMUSP00000135807
Ensembl peptide - ENSMUSP00000107123
Ensembl peptide - ENSMUSP00000122939
NCBI entrez gene - 67469     See in Manteia.
MGI - MGI:1914719
RefSeq - XM_006512245
RefSeq - NM_001359207
RefSeq - NM_026179
RefSeq - XM_006512244
RefSeq Peptide - NP_001346136
RefSeq Peptide - NP_080455
swissprot - D3Z7K3
swissprot - H3BLJ0
swissprot - H3BKV1
swissprot - Q9DBL9
Ensembl - ENSMUSG00000032540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abhd5bENSDARG00000100388Danio rerio
 ABHD5ENSGALG00000040363Gallus gallus
 ABHD5ENSG00000011198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abhd4 / abhydrolase domain containing 4 / Q8TB40*ENSMUSG0000004099753


Protein motifs (from Interpro)
Interpro ID Name
 IPR000073  Alpha/beta hydrolase fold-1
 IPR002410  Peptidase S33
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process ISO
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process ISS
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0010891 negative regulation of sequestering of triglyceride IDA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050996 positive regulation of lipid catabolic process IMP
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042171 lysophosphatidic acid acyltransferase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1tm2.1Tlu/Pax1tm2.1Tlu
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1tm2.1Tlu/Pax1tm2.1Tlu
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Abhd5tm1Murm/Abhd5tm1Murm
Genetic Background: B6.129S-Abhd5tm1Murm

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009611 epidermis stratum spinosum hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0010359 increased liver free fatty acids level "elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0010535 myocardial steatosis "an accumulation of fat deposits in the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0011579 decreased lipoprotein lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0011582 decreased triglyceride lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0012232 abnormal ceramide level 
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Allelic Composition: Abhd5tm1Murm/Abhd5tm1Murm
Genetic Background: B6.129S-Abhd5tm1Murm

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Abhd5tm1.1Lqyu/Abhd5tm1.1Lqyu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Abhd5tm1Rze/Abhd5tm1Rze,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030546 Plin1 / Q8CGN5 / Perilipin-1 / O60240*  / complex






 

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