ENSMUSG00000028494


Mus musculus

Features
Gene ID: ENSMUSG00000028494
  
Biological name :Plin2
  
Synonyms : P43883 / Perilipin-2 / Plin2
  
Possible biological names infered from orthology : Q99541
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C4
Gene start: 86648386
Gene end: 86670060
  
Corresponding Affymetrix probe sets: 10514221 (MoGene1.0st)   1448318_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119063
Ensembl peptide - ENSMUSP00000123456
Ensembl peptide - ENSMUSP00000123333
Ensembl peptide - ENSMUSP00000000466
NCBI entrez gene - 11520     See in Manteia.
MGI - MGI:87920
RefSeq - XM_006537557
RefSeq - XM_011249907
RefSeq - NM_007408
RefSeq Peptide - NP_031434
swissprot - P43883
swissprot - B1AXR5
swissprot - B1AXR3
Ensembl - ENSMUSG00000028494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plin2ENSDARG00000042332Danio rerio
 PLIN2ENSGALG00000015090Gallus gallus
 PLIN2ENSG00000147872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plin3 / Q9DBG5 / Perilipin-3 / O60664*ENSMUSG0000002419741
Plin5 / Q8BVZ1 / Perilipin-5 / Q00G26*ENSMUSG0000001130531
Plin1 / Q8CGN5 / Perilipin-1 / O60240*ENSMUSG0000003054622
Plin4 / O88492 / Perilipin-4 / Q96Q06*ENSMUSG0000000283121


Protein motifs (from Interpro)
Interpro ID Name
 IPR004279  Perilipin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0015909 long-chain fatty acid transport IDA
 biological_processGO:0019915 lipid storage IDA
 biological_processGO:0042493 response to drug IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ilktm2Star/Ilk+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ilktm2Star/Ilk+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ilktm2Star/Ilk+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0002991 abnormal sebaceous gland physiology "anomalous fundtion of any of the small, sacculated organs found within the dermis that normally secrete sebum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-Nfatct1*)1Grc/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N

Allelic Composition: Plin2tm1Itl/Plin2tm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-Nfatct1*)1Grc/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0008779 abnormal maternal behavior "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0011233 abnormal vitamin A metabolism "altered ability to metabolize any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-Nfatct1*)1Grc/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N

Allelic Composition: Plin2tm1Itl/Plin2tm1Itl,Rpe65tm1Tmr/Rpe65tm1Tmr,Tyrc-2J/Tyrc-2J
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Plin2tm1.1Asg/Plin2tm1.1Asg
Genetic Background: B6.129S2(Cg)-Plin2tm1.1Asg

 MP:0012725 small sebaceous gland "decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

 MP:0013193 sebaceous gland hypoplasia "underdevelopment and decreased size of the sebum secreting glands of the hair shaft, usually due to a decrease in the number of cells" [MGI:anna]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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