ENSMUSG00000048402


Mus musculus

Features
Gene ID: ENSMUSG00000048402
  
Biological name :Gli2
  
Synonyms : Gli2 / Q0VGT2 / Zinc finger protein GLI2
  
Possible biological names infered from orthology : GLI family zinc finger 2 / P10070
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 118834132
Gene end: 119053619
  
Corresponding Affymetrix probe sets: 10357137 (MoGene1.0st)   1446086_s_at (Mouse Genome 430 2.0 Array)   1459211_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124132
Ensembl peptide - ENSMUSP00000125661
Ensembl peptide - ENSMUSP00000125634
Ensembl peptide - ENSMUSP00000125342
Ensembl peptide - ENSMUSP00000125059
Ensembl peptide - ENSMUSP00000124768
Ensembl peptide - ENSMUSP00000054837
Ensembl peptide - ENSMUSP00000123808
NCBI entrez gene - 14633     See in Manteia.
MGI - MGI:95728
RefSeq - XM_011247924
RefSeq - NM_001081125
RefSeq - XM_006529141
RefSeq Peptide - NP_001074594
swissprot - F6UUE3
swissprot - A5AA26
swissprot - A5AA27
swissprot - Q0VGT2
swissprot - A5AA25
swissprot - A0A1B0GXK7
swissprot - A5A9W5
Ensembl - ENSMUSG00000048402
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gli2bENSDARG00000020884Danio rerio
 GLI2ENSGALG00000011630Gallus gallus
 GLI2ENSG00000074047Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131845
Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*ENSMUSG0000002540728
Glis3 / Q6XP49 / Zinc finger protein GLIS3 / Q8NEA6* / GLIS family zinc finger 3*ENSMUSG0000005294217
Glis1 / Q8K1M4 / Zinc finger protein GLIS1 / Q8NBF1* / GLIS family zinc finger 1*ENSMUSG0000003476214
Glis2 / Q8VDL9 / Zinc finger protein GLIS2 / Q9BZE0* / GLIS family zinc finger 2*ENSMUSG0000001430312
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG000000417039
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG000000678609
Zic1 / P46684 / zinc finger protein of the cerebellum 1 / Q15915* / Zic family member 1*ENSMUSG000000323689
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG000000615249
Zic4 / Q61467 / zinc finger protein of the cerebellum 4 / Q8N9L1* / Zic family member 4*ENSMUSG000000369727


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001649 osteoblast differentiation ISO
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0002062 chondrocyte differentiation IGI
 biological_processGO:0002076 osteoblast development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007418 ventral midline development IMP
 biological_processGO:0007442 hindgut morphogenesis IMP
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009913 epidermal cell differentiation ISO
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0009954 proximal/distal pattern formation IGI
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IMP
 biological_processGO:0021517 ventral spinal cord development IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021696 cerebellar cortex morphogenesis IMP
 biological_processGO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification IGI
 biological_processGO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IGI
 biological_processGO:0021904 dorsal/ventral neural tube patterning IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IMP
 biological_processGO:0021965 spinal cord ventral commissure morphogenesis IMP
 biological_processGO:0021983 pituitary gland development IGI
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IMP
 biological_processGO:0035295 tube development IGI
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IGI
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048566 embryonic digestive tract development IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IGI
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048856 anatomical structure development IMP
 biological_processGO:0060032 notochord regression IGI
 biological_processGO:0060322 head development IMP
 biological_processGO:0060513 prostatic bud formation IMP
 biological_processGO:0060603 mammary gland duct morphogenesis IMP
 biological_processGO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0098586 cellular response to virus ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097542 ciliary tip IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000431 absent palatine shelf "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gli2tm3.1(Gli1)Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm6.1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm6.1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6Alj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000867 abnormal anterior vermis "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm6.1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PitpnaGt(OST1152)Lex/PitpnaGt(OST1152)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gli2tm5(GLI3)Alj/Gli2tm5(GLI3)Alj
Genetic Background: involves: Swiss Webster

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Tmem107schlei/Tmem107schlei
Genetic Background: involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6J

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gli2tm5(GLI3)Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pax63Neu/Pax63Neu
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001181 absent lungs "missing organs of respiration" [J:51966, J:50768]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm2.1(Gli3)Blnw/Gli2tm2.1(Gli3)Blnw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm2.1Alj/Gli2+,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gli2tm3.1(Gli1)Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm3.1(Gli1)Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Kif7maki/Kif7maki,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gli2tm1Alj/Gli2+,Kif7tm1.2Hui/Kif7tm1.2Hui
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * CD-1

Allelic Composition: Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli2tm5(GLI3)Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ift122sopb/Ift122sopb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Marcksl1tm1Stl/Marcksl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gli2tm2.1Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Gli2tm5(GLI3)Alj/Gli2tm5(GLI3)Alj
Genetic Background: involves: Swiss Webster

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003159 abnormal esophageal smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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 MP:0003160 abnormal esophageal development "aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003276 esophageal atresia "congenital blockage or absence of the lumen of the esophagus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli2tm5(GLI3)Alj/Gli2tm5(GLI3)Alj
Genetic Background: involves: Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster

Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004449 absent presphenoid bone "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004544 absent esophagus "absence of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0004683 absent intervertebral disk "absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004711 persistence of notochord tissue "failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0004790 absent upper incisors "missing the upper pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004791 absent lower incisors "missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj,Shhtm1Chg/Shhtm1Chg
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm6.1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0005315 absent pituitary gland "missing gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Marcksl1tm1Stl/Marcksl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm3.1(Gli1)Alj/Gli2+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm3.1(Gli1)Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009569 abnormal left lung morphology "any structural anomaly of the organ of respiration located on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009570 abnormal right lung morphology "any structural anomaly of the organ of respiration located on the right side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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 MP:0009571 abnormal right lung accessory lobe morphology 
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009572 abnormal right lung cranial lobe morphology 
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm6.1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Pax6Sey/Pax6Sey
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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 MP:0010824 absent right lung accessory lobe "absence of the right lung lobe which lies against the diaphragm and has a considerable volume residing in the left hemi-thorax" [ISBN:0486631850 "Green, E Biology Of The Laboratory Mouse", PMID:2050021]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0010827 small lung saccule "reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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 MP:0010881 esophagus hypoplasia "underdevelopment or decreased size of the esophagus, usually due a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0010882 trachea hypoplasia "underdevelopment or reduced size of the trachea, usually due a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0010883 trachea stenosis "abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010884 esophagus stenosis "abnormal narrowing or constriction of the esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0010885 absent trachea "absence of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010906 abnormal lung bud morphology "any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: Swiss Webster

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Gli2tm6.1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gli2tm1Alj/Gli2tm6.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gli2tm2.1Alj/Gli2tm3(Gli1)Alj
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Dtnatm1Jrs/Dtnatm1Jrs,Utrntm1Jrs/Utrntm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013496 abnormal trachea development "aberrant formation or incomplete differentiation of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:Anna]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0013785 abnormal mammary gland bud morphology "any structural anomaly of the morphologically distinct bulb of epithelial cells formed once each mammary placode expands and invaginates into the underlying mesenchyme; in mouse embryos at E12.5, each epithelial bud with its contiguous mesenchyme is elevated above the surrounding ectoderm as a knob or dome; at E13.5, the buds sink into the underlying dermal mesenchyme, and by E14.5 they can no longer be detected externally; in female mouse embryos, five pairs of anlagen or buds are formed along the mammary line between E12.5 and E14.5 by proliferation of basal epidermal cells; while further mammary development is temporarily arrested in females, androgen receptor activation in male embryos causes degeneration of the buds between E13.5 and E15.5; in female mice, further development is resumed at around E15.5 when each bud elongates to form a mammary cord (sprout), invading the underlying fat pad precursor" [http://www.informatics.jax.org/greenbook/frames/frame13.shtml, MGI:Anna, PMID:12558599]
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Allelic Composition: Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gli2tm2.1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

 MP:0030255 abnormal maxillary dental arch morphology "any structural anomaly of the dental arch formed by the teeth of the maxilla (upper jaw bone)" [MGI:anna]
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Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

 MP:0030301 abnormal maxillary frontal process morphology "any structural anomaly of the upward extension from the body of the maxilla which articulates with the frontal bone; the frontal process has a vertical ridge which constitutes the medial border of the orbit (anterior lacrimal crest); posteriorly it forms the lacrimal groove together with the lacrimal bone; superomedially it is in close contact with the anterior ethmoidal sinuses" [http://www.medilexicon.com/dictionary/72273, https://www.kenhub.com/en/library/anatomy/the-maxilla]
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Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030331 absent temporomandibular joint disk "missing the oval, biconcave, avascular fibrocartilaginous structure located between the condyle of the mandible and the mandibular (glenoid) fossa of the temporal bone; the disk provides the gliding surface for the mandibular condyle, resulting in smooth joint movement; it splits the temporomandibular joint into two synovial joint cavities, each lined by a synovial membrane, and separates translational and rotational motion" [MGI:anna]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000025231 Sufu / Q9Z0P7 / SUFU negative regulator of hedgehog signaling / Q9UMX1*  / complex / reaction
 ENSMUSG00000032308 Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*  / reaction
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex / reaction
 ENSMUSG00000026361 Cdc73 / Q8JZM7 / Parafibromin / Q6P1J9* / cell division cycle 73*  / complex / reaction
 ENSMUSG00000057522 Spop / Q6ZWS8 / Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / O43791* / speckle type BTB/POZ protein*  / complex / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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