ENSMUSG00000036972


Mus musculus

Features
Gene ID: ENSMUSG00000036972
  
Biological name :Zic4
  
Synonyms : Q61467 / Zic4 / zinc finger protein of the cerebellum 4
  
Possible biological names infered from orthology : Q8N9L1 / Zic family member 4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.2
Gene start: 91362413
Gene end: 91389348
  
Corresponding Affymetrix probe sets: 10587782 (MoGene1.0st)   1421539_at (Mouse Genome 430 2.0 Array)   1456417_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134364
Ensembl peptide - ENSMUSP00000069568
Ensembl peptide - ENSMUSP00000133808
Ensembl peptide - ENSMUSP00000133958
Ensembl peptide - ENSMUSP00000133974
Ensembl peptide - ENSMUSP00000134053
NCBI entrez gene - 22774     See in Manteia.
MGI - MGI:107201
RefSeq - XM_017313292
RefSeq - XM_011242723
RefSeq - XM_011242725
RefSeq - XM_011242726
RefSeq - XM_011242727
RefSeq - XM_017313289
RefSeq - XM_017313291
RefSeq - NM_009576
RefSeq - XM_006511067
RefSeq - XM_006511078
RefSeq - XM_006511079
RefSeq - XM_006511080
RefSeq Peptide - NP_033602
swissprot - G3UYE7
swissprot - G3UZ66
swissprot - G3UY76
swissprot - G3UXS7
swissprot - Q61467
Ensembl - ENSMUSG00000036972
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zic4ENSDARG00000031307Danio rerio
 ZIC4ENSGALG00000006810Gallus gallus
 ZIC4ENSG00000174963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zic1 / P46684 / zinc finger protein of the cerebellum 1 / Q15915* / Zic family member 1*ENSMUSG0000003236859
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG0000004170359
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG0000006152459
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG0000006786055
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131833
Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*ENSMUSG0000002540732
Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*ENSMUSG0000004840232
Glis3 / Q6XP49 / Zinc finger protein GLIS3 / Q8NEA6* / GLIS family zinc finger 3*ENSMUSG0000005294229
Glis1 / Q8K1M4 / Zinc finger protein GLIS1 / Q8NBF1* / GLIS family zinc finger 1*ENSMUSG0000003476228
Glis2 / Q8VDL9 / Zinc finger protein GLIS2 / Q9BZE0* / GLIS family zinc finger 2*ENSMUSG0000001430328


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
Show

Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000866 vermis hypoplasia "reduced cell number in the vermis" [J:61509]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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