| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
|
| MP:0000373 | belly spot | "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Zic2Ku/Zic2+
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0000433 | microcephaly | "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Shroom3m1Nisw/Shroom3m1Nisw
Genetic Background: 129S1.B6-Shroom3m1Nisw
|
| MP:0000572 | abnormal autopod morphology | "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Zic2Ku/Zic2+
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
|
| MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
|
| MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
|
| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000818 | abnormal amygdala morphology | "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
|
| MP:0000819 | abnormal olfactory bulb morphology | "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
|
| MP:0000923 | abnormal roof plate morphology | "malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001044 | abnormal enteric nervous system morphology | "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
|
| MP:0001046 | abnormal enteric neuron morphology | "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
|
| MP:0001299 | abnormal eye distance/ position | "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2Ku/Zic2+
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
|
| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
Show
Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
|
| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
|
| MP:0001488 | increased startle reflex | "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
|
| MP:0001890 | anencephaly | "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002115 | abnormal skeleton extremities morphology | "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
|
| MP:0002825 | abnormal notochord | "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0003051 | curly tail | "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Zic2Ku/Zic2+
Genetic Background: C3.CAnNCrl-Zic2Ku
Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
Allelic Composition: Zic2em1Bend/Zic2+
Genetic Background: involves: C57BL/6J
Allelic Composition: Zic2em2Bend/Zic2+
Genetic Background: involves: C3H/HeH
Allelic Composition: Zic2em3Bend/Zic2+
Genetic Background: involves: C3H/HeH
Allelic Composition: Zic2em4Bend/Zic2+
Genetic Background: involves: C3H/HeH
Allelic Composition: Zic2em5Bend/Zic2+
Genetic Background: involves: C3H/HeH
|
| MP:0003054 | spina bifida | "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Zic2Ku/Zic2+
Genetic Background: C3.CAnNCrl-Zic2Ku
Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
|
| MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0003861 | abnormal nervous system development | "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0003863 | decreased aggression towards mice | "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0003895 | increased ectoderm apoptosis | "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0004066 | abnormal Henson s node morphology | "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0004180 | failure of initiation of embryo turning | "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Shhtm1Chg/Shhtm1Chg,Zic2Ku/Zic2Ku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
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| MP:0004387 | abnormal prechordal plate morphology | "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
|
| MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004613 | fusion of vertebral arches | "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004639 | fused metacarpal bones | "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004642 | fused metatarsal bones | "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004837 | abnormal neural fold formation | "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005157 | holoprosencephaly | "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0005163 | cyclopia | "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0005657 | abnormal neural plate morphology | "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0006197 | ocular hypotelorism | "the distance between the eyes is reduced" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0006282 | abnormal posterior horn morphology | "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0006290 | proboscis | "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0008415 | abnormal neurite morphology | "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572] |
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Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
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| MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0008540 | abnormal cerebrum morphology | "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0008817 | hematoma | "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0008915 | fused carpal bones | "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008919 | fused tarsal bones | "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0009142 | decreased prepulse inhibition | "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009266 | abnormal mesendoderm development | "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: 129S(Cg)-Nodaltm2Rob
|
| MP:0009454 | impaired contextual conditioning | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0009456 | impaired cued conditioning behavior | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax
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| MP:0009843 | decreased neural crest cell number | "reduction in the number of ransient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0010155 | abnormal intestine physiology | "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Zic2tm1Jaru/Zic2tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0012157 | rostral body truncation | "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith] |
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Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
Allelic Composition: Nodaltm2Rob/Nodal+,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku
Allelic Composition: Nodaltm2Rob/Nodaltm2Rob,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku
Allelic Composition: Nodaltm2Rob/Nodaltm2Rob,Zic2Ku/Zic2+
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku
Allelic Composition: Nodaltm1Rob/Nodal+,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm1Rob Zic2Ku
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| MP:0012709 | delayed caudal neuropore closure | "a delay in the joining together of the neural folds of the caudal opening of the neural tube" [MGI:anna] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0012793 | decreased rhombomere 3 size | "reduced size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0012801 | decreased rhombomere 5 size | "reduced size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna] |
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Allelic Composition: Zic2Ku/Zic2Ku
Genetic Background: C3.CAnNCrl-Zic2Ku
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| MP:0013001 | abnormal enteric neural crest cell morphology | " any structural anomaly of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; neural crest cells are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans)" [MGI:anna, PMID:17514199] |
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Allelic Composition: Zic2m1Nisw/Zic2m1Nisw
Genetic Background: 129S1.B6-Zic2m1Nisw
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