| MP:0000087 | absent mandible | "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000433 | microcephaly | "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000808 | abnormal hippocampus development | "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000820 | abnormal choroid plexus morphology | "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000827 | dilated third ventricle | "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000830 | abnormal diencephalon morphology | "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000837 | abnormal hypothalamus morphology | "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000935 | abnormal folding of telencephalic vesicles | "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001081 | abnormal cranial ganglia morphology | "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001092 | abnormal trigeminal ganglion morphology | "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001096 | abnormal glossopharyngeal ganglion morphology | "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001504 | abnormal posture | "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002639 | micrognathia | "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0003425 | abnormal optic vesicle formation | "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004081 | abnormal globus pallidus morphology | "malformation of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004592 | small mandible | "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0004870 | small premaxilla | "reduced size of the anterior and interior portion of the maxilla" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005358 | abnormal incisor morphology | "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0006007 | abnormal basal ganglion morphology | "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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| MP:0020527 | small thalamus | "decreased size of the thalamus" [MGI:smb] |
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Allelic Composition: Zic5tm1Sia/Zic5tm1Sia
Genetic Background: involves: C57BL/6 * CBA
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