ENSMUSG00000014303


Mus musculus

Features
Gene ID: ENSMUSG00000014303
  
Biological name :Glis2
  
Synonyms : Glis2 / Q8VDL9 / Zinc finger protein GLIS2
  
Possible biological names infered from orthology : GLIS family zinc finger 2 / Q9BZE0
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 4594713
Gene end: 4624924
  
Corresponding Affymetrix probe sets: 10433264 (MoGene1.0st)   1416598_at (Mouse Genome 430 2.0 Array)   1416599_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014447
Ensembl peptide - ENSMUSP00000115728
NCBI entrez gene - 83396     See in Manteia.
MGI - MGI:1932535
RefSeq - XM_011246050
RefSeq - NM_031184
RefSeq - XM_006522768
RefSeq - XM_011246048
RefSeq - XM_011246049
RefSeq Peptide - NP_112461
swissprot - Q8VDL9
swissprot - D3YYX4
Ensembl - ENSMUSG00000014303
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glis2aENSDARG00000078388Danio rerio
 glis2bENSDARG00000100232Danio rerio
 GLIS2ENSGALG00000034737Gallus gallus
 GLIS2ENSG00000126603Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*ENSMUSG0000004840235
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131830
Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*ENSMUSG0000002540729
Glis3 / Q6XP49 / Zinc finger protein GLIS3 / Q8NEA6* / GLIS family zinc finger 3*ENSMUSG0000005294226
Glis1 / Q8K1M4 / Zinc finger protein GLIS1 / Q8NBF1* / GLIS family zinc finger 1*ENSMUSG0000003476224
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG0000004170320
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG0000006152419
Zic1 / P46684 / zinc finger protein of the cerebellum 1 / Q15915* / Zic family member 1*ENSMUSG0000003236818
Zic4 / Q61467 / zinc finger protein of the cerebellum 4 / Q8N9L1* / Zic family member 4*ENSMUSG0000003697218
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG0000006786018


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development IMP
 biological_processGO:0061005 cell differentiation involved in kidney development IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnn2bc-3J/Kcnn2bc-3J
Genetic Background: C3H/HeSn-bc3J

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011422 kidney medulla atrophy "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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