ENSMUSG00000034762


Mus musculus

Features
Gene ID: ENSMUSG00000034762
  
Biological name :Glis1
  
Synonyms : Glis1 / Q8K1M4 / Zinc finger protein GLIS1
  
Possible biological names infered from orthology : GLIS family zinc finger 1 / Q8NBF1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 107434591
Gene end: 107635061
  
Corresponding Affymetrix probe sets: 10506701 (MoGene1.0st)   1425423_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118600
Ensembl peptide - ENSMUSP00000035650
Ensembl peptide - ENSMUSP00000102349
NCBI entrez gene - 230587     See in Manteia.
MGI - MGI:2386723
RefSeq - XM_017320135
RefSeq - XM_006502973
RefSeq - XM_006502974
RefSeq - XM_006502975
RefSeq - XM_011240485
RefSeq - NM_147221
RefSeq - XM_006502972
RefSeq Peptide - NP_671754
swissprot - B1ASP5
swissprot - A2A8S0
swissprot - Q8K1M4
Ensembl - ENSMUSG00000034762
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glis1aENSDARG00000068580Danio rerio
 glis1bENSDARG00000027933Danio rerio
 GLIS1ENSGALG00000010721Gallus gallus
 GLIS1ENSG00000174332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Glis3 / Q6XP49 / Zinc finger protein GLIS3 / Q8NEA6* / GLIS family zinc finger 3*ENSMUSG0000005294238
Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*ENSMUSG0000004840228
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131826
Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*ENSMUSG0000002540721
Glis2 / Q8VDL9 / Zinc finger protein GLIS2 / Q9BZE0* / GLIS family zinc finger 2*ENSMUSG0000001430316
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG0000004170315
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG0000006152414
Zic1 / P46684 / zinc finger protein of the cerebellum 1 / Q15915* / Zic family member 1*ENSMUSG0000003236813
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG0000006786012
Zic4 / Q61467 / zinc finger protein of the cerebellum 4 / Q8N9L1* / Zic family member 4*ENSMUSG0000003697212


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR030430  Zinc finger protein GLIS1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3Xt/Gli3Xt,Glis1tm1Mnks/Glis1tm1Mnks
Genetic Background: mixed

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Glis1tm1Mnks/Glis1tm1Mnks
Genetic Background: mixed

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Glis1tm1Mnks/Glis1tm1Mnks
Genetic Background: mixed

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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