ENSMUSG00000025407


Mus musculus

Features
Gene ID: ENSMUSG00000025407
  
Biological name :Gli1
  
Synonyms : Gli1 / P47806 / Zinc finger protein GLI1
  
Possible biological names infered from orthology : GLI family zinc finger 1 / P08151
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 127329882
Gene end: 127341974
  
Corresponding Affymetrix probe sets: 10373179 (MoGene1.0st)   1449058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151718
Ensembl peptide - ENSMUSP00000151749
Ensembl peptide - ENSMUSP00000026474
NCBI entrez gene - 14632     See in Manteia.
MGI - MGI:95727
RefSeq - NM_010296
RefSeq Peptide - NP_034426
swissprot - D4Q8I4
swissprot - P47806
Ensembl - ENSMUSG00000025407
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gli1ENSDARG00000101244Danio rerio
 GLI1ENSG00000111087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*ENSMUSG0000004840239
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131837
Glis3 / Q6XP49 / Zinc finger protein GLIS3 / Q8NEA6* / GLIS family zinc finger 3*ENSMUSG0000005294217
Glis1 / Q8K1M4 / Zinc finger protein GLIS1 / Q8NBF1* / GLIS family zinc finger 1*ENSMUSG0000003476215
Glis2 / Q8VDL9 / Zinc finger protein GLIS2 / Q9BZE0* / GLIS family zinc finger 2*ENSMUSG0000001430314
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG0000006152411
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG0000004170311
Zic1 / P46684 / zinc finger protein of the cerebellum 1 / Q15915* / Zic family member 1*ENSMUSG0000003236810
Zic4 / Q61467 / zinc finger protein of the cerebellum 4 / Q8N9L1* / Zic family member 4*ENSMUSG0000003697210
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG0000006786010


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR032850  Zinc finger protein GLI1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IDA
 biological_processGO:0007418 ventral midline development IGI
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0009913 epidermal cell differentiation IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0009954 proximal/distal pattern formation IGI
 biological_processGO:0021696 cerebellar cortex morphogenesis IGI
 biological_processGO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IGI
 biological_processGO:0021983 pituitary gland development IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IGI
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0045667 regulation of osteoblast differentiation IMP
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060032 notochord regression IGI
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1902808 positive regulation of cell cycle G1/S phase transition IEA
 biological_processGO:2000345 regulation of hepatocyte proliferation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0097542 ciliary tip IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of GLI1 by the proteasome
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/Sv * CD-1

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gata6tm2.1Sad/Gata6tm2.1Sad,Gli1tm1Alj/Gli1tm1Alj,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm1Alj/Gli2tm6Alj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: En1tm2(cre)Gld/En1+,Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm6Alj
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PitpnaGt(OST1152)Lex/PitpnaGt(OST1152)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
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Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm3(cre/ERT2)Alj/Gli1+,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Colqtm2Jrs/Colqtm2Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Glis1tm1Mnks/Glis1tm1Mnks
Genetic Background: mixed

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003553 abnormal foreskin morphology "anomaly of the loose fold of skin that covers the penis" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mkxtm1.1Asah/Mkxtm1.1Asah
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: PitpnaGt(OST1152)Lex/PitpnaGt(OST1152)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm1Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mkxtm1.1Asah/Mkxtm1.1Asah
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0004711 persistence of notochord tissue "failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0005315 absent pituitary gland "missing gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Shhtm1Chg/Shh+,Tg(Shh)#Dje/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm3(cre/ERT2)Alj/Gli1+,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Artm2Ska/Y,Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009569 abnormal left lung morphology "any structural anomaly of the organ of respiration located on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009571 abnormal right lung accessory lobe morphology 
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009572 abnormal right lung cranial lobe morphology 
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj,Gli3Xt/Gli3Xt
Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gli1tm1Alj/Gli1tm1Alj,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027598 Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000026361 Cdc73 / Q8JZM7 / Parafibromin / Q6P1J9* / cell division cycle 73*  / complex / reaction
 ENSMUSG00000021224 Numb / Q9QZS3 / NUMB, endocytic adaptor protein / P49757*  / complex / reaction
 ENSMUSG00000025231 Sufu / Q9Z0P7 / SUFU negative regulator of hedgehog signaling / Q9UMX1*  / complex / reaction
 ENSMUSG00000032308 Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2*  / reaction






 

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