ENSDARG00000101244


Danio rerio

Features
Gene ID: ENSDARG00000101244
  
Biological name :gli1
  
Synonyms : gli1 / GLI family zinc finger 1
  
Possible biological names infered from orthology : P08151 / P47806 / Zinc finger protein GLI1
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 59426148
Gene end: 59505589
  
Corresponding Affymetrix probe sets: Dr.24958.1.S1_at (Zebrafish Array)   NM_178296_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000129932
NCBI entrez gene - 352930     See in Manteia.
RefSeq - NM_178296
RefSeq Peptide - NP_840081
swissprot - F1QAC4
ZFIN ID - ZDB-GENE-030321-1
Ensembl - ENSDARG00000101244
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GLI1ENSG00000111087Homo sapiens
 Gli1ENSMUSG00000025407Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gli2a / GLI family zinc finger 2aENSDARG0000002564136
gli2b / GLI family zinc finger 2b / GLI2* / P10070* / GLI family zinc finger 2*ENSDARG0000002088433
gli3 / GLI family zinc finger 3ENSDARG0000005213132
glis3 / GLIS family zinc finger 3 / Q6XP49* / Q8NEA6* / Zinc finger protein GLIS3 *ENSDARG0000006972612
glis1b / GLIS family zinc finger 1b / GLIS1* / Q8K1M4* / Q8NBF1* / GLIS family zinc finger 1* / Zinc finger protein GLIS1 *ENSDARG0000002793310
glis2b / GLIS family zinc finger 2b / GLIS2* / Q8VDL9* / Q9BZE0* / GLIS family zinc finger 2* / Zinc finger protein GLIS2 *ENSDARG0000010023210
zic5 / zic family member 5 (odd-paired homolog, Drosophila) / Q96T25* / Zic family member 5* / zinc finger protein of the cerebellum 5*ENSDARG000000160229
zic1 / zic family member 1 (odd-paired homolog, Drosophila)ENSDARG000000155679
zic4 / zic family member 4 / Q61467* / Q8N9L1* / zinc finger protein of the cerebellum 4*ENSDARG000000313079
glis1a / GLIS family zinc finger 1a / GLIS1* / Q8K1M4* / Q8NBF1* / GLIS family zinc finger 1* / Zinc finger protein GLIS1 *ENSDARG000000685809
zic3 / zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) / Q62521* / O60481* / Zic family member 3* / zinc finger protein of the cerebellum 3*ENSDARG000000714979
zic2a / zic family member 2 (odd-paired homolog, Drosophila), a / ZIC2* / O95409* / Zic family member 2* / zinc finger protein of the cerebellum 2*ENSDARG000000155549
glis2a / GLIS family zinc finger 2a / GLIS2* / Q9BZE0* / GLIS family zinc finger 2*ENSDARG000000783889
zic6 / zic family member 6ENSDARG000000714968
zic2b / zic family member 2 (odd-paired homolog, Drosophila) b / ZIC2* / O95409* / Zic family member 2* / zinc finger protein of the cerebellum 2*ENSDARG000000371788
si:dkey-149i17.7ENSDARG000000946845


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR032850  Zinc finger protein GLI1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021521 ventral spinal cord interneuron specification IMP
 biological_processGO:0021532 neural tube patterning IMP
 biological_processGO:0021545 cranial nerve development IMP
 biological_processGO:0021559 trigeminal nerve development IMP
 biological_processGO:0021560 abducens nerve development IMP
 biological_processGO:0021561 facial nerve development IMP
 biological_processGO:0021563 glossopharyngeal nerve development IMP
 biological_processGO:0021564 vagus nerve development IMP
 biological_processGO:0021731 trigeminal motor nucleus development IMP
 biological_processGO:0021742 abducens nucleus development IMP
 biological_processGO:0021754 facial nucleus development IMP
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0042694 muscle cell fate specification IGI
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0048855 adenohypophysis morphogenesis IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 cellular_componentGO:0035301 Hedgehog signaling complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Degradation of GLI1 by the proteasome
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000012 central nervous system central nervous system has fewer parts of type white matter , abnormal
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 ZFA:0000022 floor plate floor plate quality , abnormal
floor plate decreased size , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure aplastic , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
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 ZFA:0000107 eye eye quality , abnormal
eye decreased distance eye , abnormal
eye mislocalised medially , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
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 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus absent , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000387 motor nucleus of vagal nerve motor nucleus of vagal nerve absent , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000556 optic chiasm optic chiasm malformed , abnormal
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 ZFA:0000668 cranial nerve IX cranial nerve IX absent , abnormal
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 ZFA:0000713 abducens motor nucleus abducens motor nucleus absent , abnormal
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 ZFA:0000938 central canal central canal quality , abnormal
central canal morphology , abnormal
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 ZFA:0001086 muscle pioneer muscle pioneer absent , abnormal
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 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism curved ventral , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region curved ventral , abnormal
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 ZFA:0001135 neural tube neural tube quality , abnormal
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 ZFA:0001198 adenohypophyseal placode adenohypophyseal placode decreased size , abnormal
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 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone decreased length , abnormal
ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth , abnormal
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 ZFA:0001256 lateral floor plate lateral floor plate composition , abnormal
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 ZFA:0001282 adenohypophysis adenohypophysis physical object quality , abnormal
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 ZFA:0001365 trigeminal motor nucleus trigeminal motor nucleus absent , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage hypoplastic , abnormal
ethmoid cartilage decreased width , abnormal
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 ZFA:0001423 parachordal cartilage parachordal cartilage fused with parachordal cartilage , abnormal
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 ZFA:0001424 chondrocranium chondrocranium morphology , abnormal
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 ZFA:0001507 trabecula cranii trabecula cranii fused with trabecula cranii , abnormal
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 ZFA:0005730 cranial motor neuron cranial motor neuron absent , abnormal
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 ZFA:0009003 cranial neural crest cell cranial neural crest cell mislocalised ventrally , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell decreased amount , abnormal
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 ZFA:0009155 somatotropin secreting cell somatotropin secreting cell decreased amount , abnormal
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 ZFA:0009204 prolactin secreting cell prolactin secreting cell decreased amount , abnormal
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 ZFA:0009216 adrenocorticotropic hormone secreting cell adrenocorticotropic hormone secreting cell decreased amount , abnormal
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 ZFA:0009244 primary motor neuron primary motor neuron axon misrouted , abnormal
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 ZFA:0009247 secondary motor neuron secondary motor neuron axon misrouted , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
retinal ganglion cell axon displaced to diencephalon , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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