ENSMUSG00000026361


Mus musculus

Features
Gene ID: ENSMUSG00000026361
  
Biological name :Cdc73
  
Synonyms : Cdc73 / Parafibromin / Q8JZM7
  
Possible biological names infered from orthology : cell division cycle 73 / Q6P1J9
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: F
Gene start: 143598800
Gene end: 143702893
  
Corresponding Affymetrix probe sets: 10358359 (MoGene1.0st)   1427971_at (Mouse Genome 430 2.0 Array)   1427972_at (Mouse Genome 430 2.0 Array)   1427973_s_at (Mouse Genome 430 2.0 Array)   1429940_at (Mouse Genome 430 2.0 Array)   1439103_at (Mouse Genome 430 2.0 Array)   1443986_at (Mouse Genome 430 2.0 Array)   1446983_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139872
Ensembl peptide - ENSMUSP00000018337
NCBI entrez gene - 214498     See in Manteia.
MGI - MGI:2384876
RefSeq - NM_145991
RefSeq Peptide - NP_666103
swissprot - A0A087WPQ2
swissprot - Q8JZM7
Ensembl - ENSMUSG00000026361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc73ENSDARG00000020201Danio rerio
 CDC73ENSGALG00000002469Gallus gallus
 CDC73ENSG00000134371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007852  Cdc73/Parafibromin
 IPR031336  Cell division control protein 73, C-terminal
 IPR032041  Paf1 complex subunit Cdc73, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001558 regulation of cell growth IMP
 biological_processGO:0001711 endodermal cell fate commitment IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0006378 mRNA polyadenylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010390 histone monoubiquitination IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016570 histone modification IBA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0033523 histone H2B ubiquitination IEA
 biological_processGO:0034402 recruitment of 3"-end processing factors to RNA polymerase II holoenzyme complex IBA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:1902808 positive regulation of cell cycle G1/S phase transition IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016593 Cdc73/Paf1 complex ISO
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the beta-catenin:TCF transactivating complex
Hedgehog on state
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

Allelic Composition: Cdc73tm1Btt/Cdc73+,Tg(PTH-cre)4167Slib/0
Genetic Background: Not Specified

Allelic Composition: Cdc73tm1Btt/Cdc73tm1Btt,Tg(PTH-cre)4167Slib/0
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0000454 abnormal jaw morphology "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129T2/SvEms * FVB/N

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0000618 small salivary gland "reduced size of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0002164 abnormal gland physiology "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0003432 increased activity of parathyroid "increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0003495 parathyroid ademona "appearance of benign neoplasms in the parathyroid gland" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

Allelic Composition: Cdc73tm1Btt/Cdc73+,Tg(PTH-cre)4167Slib/0
Genetic Background: Not Specified

Allelic Composition: Cdc73tm1Btt/Cdc73tm1Btt,Tg(PTH-cre)4167Slib/0
Genetic Background: Not Specified

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

 MP:0010321 increased parathyroid gland tumor incidence "greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc73Gt(RRE190)Byg/Cdc73+
Genetic Background: B6.129P2-Cdc73Gt(RRE190)Byg

Allelic Composition: Cdc73tm1Btt/Cdc73+,Tg(PTH-cre)4167Slib/0
Genetic Background: Not Specified

Allelic Composition: Cdc73tm1Btt/Cdc73tm1Btt,Tg(PTH-cre)4167Slib/0
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0012118 absent trophectoderm cell proliferation 
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b-cH
Genetic Background: involves: 101/H * C3H/HeH * T Stock

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000042487 Leo1 / Q5XJE5 / RNA polymerase-associated protein LEO1 / Q8WVC0* / LEO1 homolog, Paf1/RNA polymerase II complex component*  / complex / reaction
 ENSMUSG00000025407 Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*  / reaction / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex
 ENSMUSG00000048402 Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*  / complex / reaction
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / reaction / complex






 

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