Manteia

ENSMUSG00000042487

Mus musculus

Features

Gene ID:	ENSMUSG00000042487

Biological name :	Leo1

Synonyms :	Leo1 / Q5XJE5 / RNA polymerase-associated protein LEO1

Possible biological names infered from orthology :	LEO1 homolog, Paf1/RNA polymerase II complex component / Q8WVC0

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	D
Gene start:	75441524
Gene end:	75466432

Corresponding Affymetrix probe sets:	10587211 (MoGene1.0st) 1455293_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046905 NCBI entrez gene - 235497 See in Manteia. MGI - MGI:2685031 RefSeq - NM_001039522 RefSeq - XM_017313344 RefSeq Peptide - NP_001034611 swissprot - Q5XJE5 Ensembl - ENSMUSG00000042487

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR007149	Leo1-like protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001711	endodermal cell fate commitment	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006368	transcription elongation from RNA polymerase II promoter	IEA
biological_process	GO:0006378	mRNA polyadenylation	IEA
biological_process	GO:0010390	histone monoubiquitination	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0016570	histone modification	IEA
biological_process	GO:0019827	stem cell population maintenance	IEA
biological_process	GO:0031442	positive regulation of mRNA 3"-end processing	IEA
biological_process	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IEA
biological_process	GO:0033523	histone H2B ubiquitination	IEA
biological_process	GO:0045638	negative regulation of myeloid cell differentiation	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
cellular_component	GO:0001650	fibrillar center	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005813	centrosome	IEA
cellular_component	GO:0016593	Cdc73/Paf1 complex	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	IBA

Pathways (from Reactome)

Pathway description

Formation of RNA Pol II elongation complex

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Krit1^{tm1.1(KOMP)Vlcg}/Krit1⁺ Genetic Background: C57BL/6N-Krit1^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000006932	Ctnnb1 / Q02248 / Catenin beta-1 / P35222*	/ reaction / complex
ENSMUSG00000026361	Cdc73 / Q8JZM7 / Parafibromin / Q6P1J9* / cell division cycle 73*	/ complex / reaction
ENSMUSG00000027985	Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*	/ complex / reaction
ENSMUSG00000024985	Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr