ENSG00000166477


Homo sapiens

Features
Gene ID: ENSG00000166477
  
Biological name :LEO1
  
Synonyms : LEO1 / LEO1 homolog, Paf1/RNA polymerase II complex component / Q8WVC0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.2
Gene start: 51938025
Gene end: 51971806
  
Corresponding Affymetrix probe sets: 235096_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299601
Ensembl peptide - ENSP00000314610
NCBI entrez gene - 123169     See in Manteia.
OMIM - 610507
RefSeq - NM_138792
RefSeq - XM_017021911
RefSeq - NM_001286430
RefSeq - NM_001323903
RefSeq - NM_001323904
RefSeq Peptide - NP_001310832
RefSeq Peptide - NP_001310833
RefSeq Peptide - NP_620147
RefSeq Peptide - NP_001273359
swissprot - Q8WVC0
Ensembl - ENSG00000166477
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 leo1ENSDARG00000055357Danio rerio
 LEO1ENSGALG00000004696Gallus gallus
 Leo1ENSMUSG00000042487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007149  Leo1-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001711 endodermal cell fate commitment ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006378 mRNA polyadenylation IMP
 biological_processGO:0010390 histone monoubiquitination IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016570 histone modification IEA
 biological_processGO:0019827 stem cell population maintenance IDA
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IMP
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0033523 histone H2B ubiquitination IDA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990269 RNA polymerase II C-terminal domain phosphoserine binding IBA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the beta-catenin:TCF transactivating complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction / complex
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000134371 CDC73 / Q6P1J9 / cell division cycle 73  / reaction / complex






 

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