ENSG00000138795


Homo sapiens

Features
Gene ID: ENSG00000138795
  
Biological name :LEF1
  
Synonyms : LEF1 / lymphoid enhancer binding factor 1 / Q9UJU2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q25
Gene start: 108047545
Gene end: 108168956
  
Corresponding Affymetrix probe sets: 210948_s_at (Human Genome U133 Plus 2.0 Array)   221557_s_at (Human Genome U133 Plus 2.0 Array)   221558_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406176
Ensembl peptide - ENSP00000422334
Ensembl peptide - ENSP00000427459
Ensembl peptide - ENSP00000427365
Ensembl peptide - ENSP00000422840
Ensembl peptide - ENSP00000422801
Ensembl peptide - ENSP00000265165
Ensembl peptide - ENSP00000369284
NCBI entrez gene - 51176     See in Manteia.
OMIM - 153245
RefSeq - XM_005263046
RefSeq - XM_006714233
RefSeq - XM_005263048
RefSeq - XM_005263047
RefSeq - NM_001130713
RefSeq - NM_001130714
RefSeq - NM_001166119
RefSeq - NM_016269
RefSeq Peptide - NP_001124185
RefSeq Peptide - NP_001124186
RefSeq Peptide - NP_001159591
RefSeq Peptide - NP_057353
swissprot - Q9UJU2
swissprot - D6RIV1
swissprot - A0A024RDI7
swissprot - D6RAB1
swissprot - D6RID7
Ensembl - ENSG00000138795
  
Related genetic diseases (OMIM): 153245 - Sebaceous tumors, somatic

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lef1ENSDARG00000031894Danio rerio
 LEF1ENSGALG00000031960Gallus gallus
 Lef1ENSMUSG00000027985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NQB0 / TCF7L2 / transcription factor 7 like 2ENSG0000014873763
Q9HCS4 / TCF7L1 / transcription factor 7 like 1ENSG0000015228457
TCF7 / P36402 / transcription factor 7ENSG0000008105945


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028769  Lymphoid enhancer-binding factor 1
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IBA
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001755 neural crest cell migration IBA
 biological_processGO:0001756 somitogenesis IBA
 biological_processGO:0001837 epithelial to mesenchymal transition ISS
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0002040 sprouting angiogenesis IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0016202 regulation of striated muscle tissue development IBA
 biological_processGO:0021542 dentate gyrus development IBA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021854 hypothalamus development IBA
 biological_processGO:0021861 forebrain radial glial cell differentiation IBA
 biological_processGO:0021873 forebrain neuroblast division IBA
 biological_processGO:0021879 forebrain neuron differentiation IBA
 biological_processGO:0021943 formation of radial glial scaffolds IBA
 biological_processGO:0022407 regulation of cell-cell adhesion IBA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030223 neutrophil differentiation IMP
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0030326 embryonic limb morphogenesis IBA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030854 positive regulation of granulocyte differentiation IDA
 biological_processGO:0030879 mammary gland development IBA
 biological_processGO:0032696 negative regulation of interleukin-13 production IDA
 biological_processGO:0032713 negative regulation of interleukin-4 production IDA
 biological_processGO:0032714 negative regulation of interleukin-5 production IDA
 biological_processGO:0033153 T cell receptor V(D)J recombination IEA
 biological_processGO:0042100 B cell proliferation IBA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0043923 positive regulation by host of viral transcription IDA
 biological_processGO:0043966 histone H3 acetylation IMP
 biological_processGO:0043967 histone H4 acetylation IMP
 biological_processGO:0045063 T-helper 1 cell differentiation ISS
 biological_processGO:0045843 negative regulation of striated muscle tissue development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046632 alpha-beta T cell differentiation IBA
 biological_processGO:0048069 eye pigmentation IBA
 biological_processGO:0048341 paraxial mesoderm formation IBA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048747 muscle fiber development IBA
 biological_processGO:0050909 sensory perception of taste IEA
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0060033 anatomical structure regression IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060325 face morphogenesis IBA
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IBA
 biological_processGO:0060710 chorio-allantoic fusion IBA
 biological_processGO:0061153 trachea gland development IBA
 biological_processGO:0071345 cellular response to cytokine stimulus IMP
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IMP
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IMP
 biological_processGO:0071895 odontoblast differentiation IBA
 biological_processGO:0071899 negative regulation of estrogen receptor binding IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:1990907 beta-catenin-TCF complex IPI
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding TAS
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008301 DNA binding, bending ISS
 molecular_functionGO:0030284 estrogen receptor activity IDA
 molecular_functionGO:0030331 estrogen receptor binding IDA
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0045295 gamma-catenin binding IPI
 molecular_functionGO:0070016 armadillo repeat domain binding IPI
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124766 SOX4 / Q06945 / SRY-box 4  / complex / reaction
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / complex / reaction
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / reaction / complex
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction / complex
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / reaction / complex
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000116128 BCL9 / O00512 / B cell CLL/lymphoma 9  / reaction / complex
 ENSG00000164362 TERT / O14746 / telomerase reverse transcriptase  / complex / reaction
 ENSG00000186174 BCL9L / Q86UU0 / B cell CLL/lymphoma 9 like  / complex / reaction
 ENSG00000196367 TRRAP / Q9Y4A5 / transformation/transcription domain associated protein  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000127616 P51532 / SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000166477 LEO1 / Q8WVC0 / LEO1 homolog, Paf1/RNA polymerase II complex component  / reaction / complex
 ENSG00000163348 PYGO2 / Q9BRQ0 / pygopus family PHD finger 2  / reaction / complex
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / complex / reaction
 ENSG00000171016 PYGO1 / Q9Y3Y4 / pygopus family PHD finger 1  / reaction / complex
 ENSG00000164736 SOX17 / Q9H6I2 / SRY-box 17  / complex / reaction
 ENSG00000143842 SOX13 / Q9UN79 / SRY-box 13  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000134371 CDC73 / Q6P1J9 / cell division cycle 73  / complex / reaction
 ENSG00000087095 NLK / Q9UBE8 / nemo like kinase  / reaction






 

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