ENSG00000163348


Homo sapiens

Features
Gene ID: ENSG00000163348
  
Biological name :PYGO2
  
Synonyms : PYGO2 / pygopus family PHD finger 2 / Q9BRQ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 154957026
Gene end: 154963853
  
Corresponding Affymetrix probe sets: 201469_s_at (Human Genome U133 Plus 2.0 Array)   225370_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357441
Ensembl peptide - ENSP00000357442
NCBI entrez gene - 90780     See in Manteia.
OMIM - 606903
RefSeq - NM_138300
RefSeq Peptide - NP_612157
swissprot - Q5T170
swissprot - Q5T171
swissprot - Q9BRQ0
Ensembl - ENSG00000163348
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pygo2ENSDARG00000036772Danio rerio
 Pygo2ENSMUSG00000047824Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PYGO1 / Q9Y3Y4 / pygopus family PHD finger 1ENSG0000017101636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007289 spermatid nucleus differentiation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0035065 regulation of histone acetylation IEA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0051569 regulation of histone H3-K4 methylation IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:1990907 beta-catenin-TCF complex IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035034 histone acetyltransferase regulator activity IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction / complex
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex
 ENSG00000186174 BCL9L / Q86UU0 / B cell CLL/lymphoma 9 like  / reaction / complex
 ENSG00000116128 BCL9 / O00512 / B cell CLL/lymphoma 9  / complex / reaction






 

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