ENSG00000152284


Homo sapiens

Features
Gene ID: ENSG00000152284
  
Biological name :TCF7L1
  
Synonyms : Q9HCS4 / TCF7L1 / transcription factor 7 like 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p11.2
Gene start: 85133410
Gene end: 85310388
  
Corresponding Affymetrix probe sets: 221016_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282111
Ensembl peptide - ENSP00000388984
NCBI entrez gene - 83439     See in Manteia.
OMIM - 604652
RefSeq - NM_031283
RefSeq - XM_006712109
RefSeq Peptide - NP_112573
swissprot - C9JPE3
swissprot - Q9HCS4
Ensembl - ENSG00000152284
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9YHE8ENSDARG00000038159Danio rerio
 tcf7l1bENSDARG00000007369Danio rerio
 Tcf7l1ENSMUSG00000055799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NQB0 / TCF7L2 / transcription factor 7 like 2ENSG0000014873762
LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1ENSG0000013879539
TCF7 / P36402 / transcription factor 7ENSG0000008105930


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028773  Transcription factor 7-like
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway NAS
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex






 

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