ENSG00000081059


Homo sapiens

Features
Gene ID: ENSG00000081059
  
Biological name :TCF7
  
Synonyms : P36402 / TCF7 / transcription factor 7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.1
Gene start: 134114711
Gene end: 134151865
  
Corresponding Affymetrix probe sets: 205254_x_at (Human Genome U133 Plus 2.0 Array)   205255_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429547
Ensembl peptide - ENSP00000429178
Ensembl peptide - ENSP00000429696
Ensembl peptide - ENSP00000431095
Ensembl peptide - ENSP00000430617
Ensembl peptide - ENSP00000430179
Ensembl peptide - ENSP00000429946
Ensembl peptide - ENSP00000429935
Ensembl peptide - ENSP00000429817
Ensembl peptide - ENSP00000340347
Ensembl peptide - ENSP00000367822
Ensembl peptide - ENSP00000378469
Ensembl peptide - ENSP00000378472
Ensembl peptide - ENSP00000427758
Ensembl peptide - ENSP00000427782
Ensembl peptide - ENSP00000427870
Ensembl peptide - ENSP00000427968
NCBI entrez gene - 6932     See in Manteia.
OMIM - 189908
RefSeq - XM_017009790
RefSeq - NM_201632
RefSeq - NM_201634
RefSeq - NM_213648
RefSeq - XM_006714678
RefSeq - XM_006714679
RefSeq - XM_006714680
RefSeq - XM_006714682
RefSeq - XM_006714684
RefSeq - XM_006714685
RefSeq - XM_006714686
RefSeq - XM_011543604
RefSeq - XM_011543606
RefSeq - XM_011543609
RefSeq - XM_011543610
RefSeq - XM_011543612
RefSeq - XM_011543613
RefSeq - XM_017009789
RefSeq - NM_001134851
RefSeq - NM_003202
RefSeq Peptide - NP_998813
RefSeq Peptide - NP_963963
RefSeq Peptide - NP_963965
RefSeq Peptide - NP_001128323
RefSeq Peptide - NP_003193
swissprot - E5RG34
swissprot - H0YAR8
swissprot - H0YBC8
swissprot - E5RJ51
swissprot - H0YBP2
swissprot - P36402
swissprot - B7WNT5
swissprot - H0YBM1
swissprot - E5RHL1
swissprot - E5RGQ1
swissprot - E5RGJ5
swissprot - E5RG75
Ensembl - ENSG00000081059
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf7ENSDARG00000038672Danio rerio
 TCF7ENSGALG00000006480Gallus gallus
 Tcf7ENSMUSG00000000782Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NQB0 / TCF7L2 / transcription factor 7 like 2ENSG0000014873750
LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1ENSG0000013879547
Q9HCS4 / TCF7L1 / transcription factor 7 like 1ENSG0000015228446


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028785  Transcription factor 7
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030538 embryonic genitalia morphogenesis IEA
 biological_processGO:0033153 T cell receptor V(D)J recombination IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IEA
 biological_processGO:0046632 alpha-beta T cell differentiation IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 biological_processGO:0048619 embryonic hindgut morphogenesis IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex






 

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