ENSMUSG00000000782


Mus musculus

Features
Gene ID: ENSMUSG00000000782
  
Biological name :Tcf7
  
Synonyms : Q00417 / Tcf7 / transcription factor 7, T cell specific
  
Possible biological names infered from orthology : P36402 / transcription factor 7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 52252371
Gene end: 52283014
  
Corresponding Affymetrix probe sets: 10385776 (MoGene1.0st)   1433471_at (Mouse Genome 430 2.0 Array)   1450461_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084055
Ensembl peptide - ENSMUSP00000104699
NCBI entrez gene - 21414     See in Manteia.
MGI - MGI:98507
RefSeq - NM_009331
RefSeq - NM_001313981
RefSeq Peptide - NP_001300910
RefSeq Peptide - NP_033357
swissprot - Q00417
swissprot - Q80UF1
Ensembl - ENSMUSG00000000782
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf7ENSDARG00000038672Danio rerio
 TCF7ENSGALG00000006480Gallus gallus
 TCF7ENSG00000081059Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*ENSMUSG0000002498551
Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*ENSMUSG0000002798550
Tcf7l1 / transcription factor 7 like 1 / Q9HCS4*ENSMUSG0000005579949


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR028785  Transcription factor 7
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0030538 embryonic genitalia morphogenesis IGI
 biological_processGO:0033153 T cell receptor V(D)J recombination IGI
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IDA
 biological_processGO:0046632 alpha-beta T cell differentiation IGI
 biological_processGO:0048557 embryonic digestive tract morphogenesis IGI
 biological_processGO:0048619 embryonic hindgut morphogenesis IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0008013 beta-catenin binding IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1+
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi/H

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1+
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi/H

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1+
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi/H

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001677 absent apical ectodermal ridge "missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [J:54637]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: ApcMin/Apc+,Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tcf7tm1Cle/Tcf7+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006302 abnormal ectomesenchyme morphology "abnormality in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches." [J:119939, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006422 mammary adenoacanthoma "higher than normal incidence of malignant tumors in which some cells have undergone squamous metaplasia in the mammary gland" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: ApcMin/Apc+,Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010318 increased salivary gland tumor incidence "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Tcf7tm1Cle/Tcf7tm1Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0013166 small forelimb buds "reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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