ENSMUSG00000055799


Mus musculus

Features
Gene ID: ENSMUSG00000055799
  
Biological name :Tcf7l1
  
Synonyms : Tcf7l1 / transcription factor 7 like 1
  
Possible biological names infered from orthology : Q9HCS4
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 72626378
Gene end: 72789254
  
Corresponding Affymetrix probe sets: 10545458 (MoGene1.0st)   1436207_at (Mouse Genome 430 2.0 Array)   1450117_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115060
Ensembl peptide - ENSMUSP00000069403
Ensembl peptide - ENSMUSP00000109687
NCBI entrez gene - 21415     See in Manteia.
MGI - MGI:1202876
RefSeq - XM_006505882
RefSeq - NM_001079822
RefSeq - NM_009332
RefSeq Peptide - NP_033358
RefSeq Peptide - NP_001073290
swissprot - A1A549
swissprot - F6VNH1
swissprot - A1A550
Ensembl - ENSMUSG00000055799
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9YHE8ENSDARG00000038159Danio rerio
 tcf7l1bENSDARG00000007369Danio rerio
 Q9HCS4ENSG00000152284Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*ENSMUSG0000002498560
Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*ENSMUSG0000002798537
Tcf7 / Q00417 / transcription factor 7, T cell specific / P36402* / transcription factor 7*ENSMUSG0000000078225


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028773  Transcription factor 7-like
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1+,Tcf7l1tm2Efu/Tcf7l1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu
Genetic Background: involves: 129S/SvEv

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu
Genetic Background: involves: 129S/SvEv

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1+,Tcf7l1tm2Efu/Tcf7l1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu
Genetic Background: involves: 129S/SvEv

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Tcf7l1tm1.1(cre/ERT2)Hng/Tcf7l1tm1.1(cre/ERT2)Hng
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tcf7l1tm1.1Bjme/Tcf7l1tm1.1Bjme
Genetic Background: involves: C57BL/6

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar,Tcf7l1tm2Efu/Tcf7l1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu
Genetic Background: involves: 129S/SvEv

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0012181 increased somite number "increase in the average number of somites formed relative to littermates or other controls" [MGI:anna]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0012274 increased axial mesoderm size "greater than average size of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
Show

Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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