ENSDARG00000038159


Danio rerio

Features
Gene ID: ENSDARG00000038159
  
Biological name :tcf7l1a
  
Synonyms : Q9YHE8 / tcf7l1a / transcription factor 7 like 1a
  
Possible biological names infered from orthology : Q9HCS4 / TCF7L1 / transcription factor 7 like 1
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 42195732
Gene end: 42297889
  
Corresponding Affymetrix probe sets: Dr.8292.1.S1_at (Zebrafish Array)   NM_131269_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000090035
Ensembl peptide - ENSDARP00000118493
NCBI entrez gene - 30523     See in Manteia.
RefSeq - NM_131269
RefSeq Peptide - NP_571344
swissprot - F1QMG3
swissprot - Q9YHE8
ZFIN ID - ZDB-GENE-980605-30
Ensembl - ENSDARG00000038159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9HCS4ENSG00000152284Homo sapiens
 Tcf7l1ENSMUSG00000055799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tcf7l1b / transcription factor 7 like 1b / Q9HCS4* / TCF7L1* / transcription factor 7 like 1*ENSDARG0000000736983
tcf7l2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*ENSDARG0000000441556
lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*ENSDARG0000003189438
tcf7 / transcription factor 7 / P36402* / Q00417* / transcription factor 7, T cell specific*ENSDARG0000003867235


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0010456 cell proliferation in dorsal spinal cord IGI
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021903 rostrocaudal neural tube patterning IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0030900 forebrain development IGI
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IGI
 biological_processGO:0048699 generation of neurons IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060323 head morphogenesis IMP
 biological_processGO:0060847 endothelial cell fate specification IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary aplastic , abnormal
Show

 ZFA:0000079 telencephalon telencephalon aplastic , abnormal
Show

 ZFA:0000080 trigeminal neural crest trigeminal neural crest distended , abnormal
Show

 ZFA:0000107 eye eye absent , abnormal
eye aplastic , abnormal
eye hypoplastic , abnormal
eye decreased size , abnormal
eye quality , abnormal
Show

 ZFA:0000109 forebrain forebrain aplastic , abnormal
forebrain decreased size , abnormal
forebrain truncated , abnormal
forebrain quality , abnormal
forebrain morphology , abnormal
Show

 ZFA:0000128 midbrain midbrain hypoplastic , abnormal
midbrain decreased size , abnormal
midbrain quality , abnormal
Show

 ZFA:0000135 notochord notochord aplastic/hypoplastic , abnormal
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 ZFA:0000162 trigeminal placode trigeminal placode neuron irregular spatial pattern , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001114 head head deformed , abnormal
head malformed , abnormal
head anterior region truncated , abnormal
head morphology , abnormal
Show

 ZFA:0001272 palatoquadrate arch palatoquadrate arch morphology , abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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