ENSDARG00000007369


Danio rerio

Features
Gene ID: ENSDARG00000007369
  
Biological name :tcf7l1b
  
Synonyms : tcf7l1b / transcription factor 7 like 1b
  
Possible biological names infered from orthology : Q9HCS4 / TCF7L1 / transcription factor 7 like 1
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 52106818
Gene end: 52230115
  
Corresponding Affymetrix probe sets: Dr.8108.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000138302
Ensembl peptide - ENSDARP00000148053
Ensembl peptide - ENSDARP00000051824
Ensembl peptide - ENSDARP00000123256
Ensembl peptide - ENSDARP00000124372
NCBI entrez gene - 30556     See in Manteia.
swissprot - B0S559
swissprot - F1R336
swissprot - F8W3L0
ZFIN ID - ZDB-GENE-991110-10
Ensembl - ENSDARG00000007369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9HCS4ENSG00000152284Homo sapiens
 Tcf7l1ENSMUSG00000055799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9YHE8 / tcf7l1a / transcription factor 7 like 1a / TCF7L1* / Q9HCS4* / transcription factor 7 like 1*ENSDARG0000003815979
tcf7l2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*ENSDARG0000000441553
lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*ENSDARG0000003189435
tcf7 / transcription factor 7 / P36402* / Q00417* / transcription factor 7, T cell specific*ENSDARG0000003867233


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028785  Transcription factor 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain wholly posterioralized , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle has extra parts of type cardiac muscle cell , abnormal
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 ZFA:0000029 hindbrain hindbrain morphology , abnormal
hindbrain constricted , abnormal
hindbrain decreased width , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary closure incomplete , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000075 spinal cord spinal cord neuroblast (sensu Vertebrata) cellular quality , abnormal
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 ZFA:0000079 telencephalon telencephalon aplastic , abnormal
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 ZFA:0000107 eye eye aplastic , abnormal
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 ZFA:0000109 forebrain forebrain morphology , abnormal
forebrain decreased size , abnormal
forebrain wholly posterioralized , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
heart linear , abnormal
heart has extra parts of type cardiac muscle cell , abnormal
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 ZFA:0000128 midbrain midbrain increased size , abnormal
midbrain decreased size , abnormal
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 ZFA:0000471 atrium atrium has extra parts of type cardiac muscle cell , abnormal
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 ZFA:0001064 rhombomere rhombomere primary neuron crowded , abnormal
rhombomere primary neuron disorganized , abnormal
rhombomere morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001114 head head morphology , abnormal
head decreased size , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature anterior region absent , abnormal
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 ZFA:0001692 hindbrain commissure hindbrain commissure neuron absent , abnormal
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 ZFA:0009149 Mauthner neuron Mauthner neuron axon decreased length , abnormal
Mauthner neuron axon fasciculation , abnormal
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 ZFA:0009292 radial glial cell radial glial cell cell projection irregular spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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