ENSDARG00000004415


Danio rerio

Features
Gene ID: ENSDARG00000004415
  
Biological name :tcf7l2
  
Synonyms : tcf7l2 / transcription factor 7 like 2
  
Possible biological names infered from orthology : Q924A0 / Q9NQB0 / transcription factor 7 like 2, T cell specific, HMG box
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 30977736
Gene end: 31103906
  
Corresponding Affymetrix probe sets: Dr.18295.1.S1_a_at (Zebrafish Array)   NM_131259_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000127271
Ensembl peptide - ENSDARP00000156708
Ensembl peptide - ENSDARP00000152928
Ensembl peptide - ENSDARP00000148961
Ensembl peptide - ENSDARP00000004631
Ensembl peptide - ENSDARP00000009531
Ensembl peptide - ENSDARP00000030292
Ensembl peptide - ENSDARP00000106073
Ensembl peptide - ENSDARP00000109147
Ensembl peptide - ENSDARP00000110854
Ensembl peptide - ENSDARP00000120808
Ensembl peptide - ENSDARP00000127119
NCBI entrez gene - 30510     See in Manteia.
RefSeq - NM_131259
RefSeq Peptide - NP_571334
swissprot - B3DKP7
swissprot - F1Q7T6
swissprot - F1QC44
swissprot - F1QLQ0
swissprot - F1RC81
swissprot - U3JA54
swissprot - U3JAK3
swissprot - E9QFQ3
swissprot - E9QC17
ZFIN ID - ZDB-GENE-991110-8
Ensembl - ENSDARG00000004415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TCF7L2ENSGALG00000008883Gallus gallus
 Q9NQB0ENSG00000148737Homo sapiens
 Q924A0ENSMUSG00000024985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9YHE8 / tcf7l1a / transcription factor 7 like 1a / TCF7L1* / Q9HCS4* / transcription factor 7 like 1*ENSDARG0000003815966
tcf7l1b / transcription factor 7 like 1b / Q9HCS4* / TCF7L1* / transcription factor 7 like 1*ENSDARG0000000736965
lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*ENSDARG0000003189447
tcf7 / transcription factor 7 / P36402* / Q00417* / transcription factor 7, T cell specific*ENSDARG0000003867243


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028773  Transcription factor 7-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0010226 response to lithium ion IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021986 habenula development IMP
 biological_processGO:0035462 determination of left/right asymmetry in diencephalon IMP
 biological_processGO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart decreased contractility , abnormal
Show

 ZFA:0000213 habenula habenula determination of left/right asymmetry in diencephalon process quality , abnormal
habenula neuron projection displaced , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased length , abnormal
whole organism decreased size , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001117 post-vent region post-vent region morphology , abnormal
Show

 ZFA:0001215 thalamus thalamus nucleus absent , abnormal
thalamus neuron absent , abnormal
Show

 ZFA:0001338 intestine intestine well differentiated , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve malformed , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium has fewer parts of type epithelial cell , abnormal
intestinal epithelium flat , abnormal
Show

 ZFA:0005125 intestinal villus intestinal villus decreased length , abnormal
intestinal villus absent , abnormal
Show

 ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium cellular quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr