ENSGALG00000008883


Gallus gallus

Features
Gene ID: ENSGALG00000008883
  
Biological name :TCF7L2
  
Synonyms : TCF7L2 / transcription factor 7 like 2
  
Possible biological names infered from orthology : Q924A0 / Q9NQB0 / transcription factor 7 like 2, T cell specific, HMG box
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 27067493
Gene end: 27239223
  
Corresponding Affymetrix probe sets: Gga.12680.1.S1_at (Chicken Array)   Gga.273.1.A1_at (Chicken Array)   Gga.273.1.S1_at (Chicken Array)   Gga.9606.1.S1_at (Chicken Array)   Gga.9606.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000032466
Ensembl peptide - ENSGALP00000049280
Ensembl peptide - ENSGALP00000014420
NCBI entrez gene - 395508     See in Manteia.
RefSeq - XM_015288570
RefSeq - XM_015288566
RefSeq - XM_015288567
RefSeq - XM_015288568
RefSeq - XM_015288569
RefSeq - NM_001206510
RefSeq - XM_015288546
RefSeq - XM_015288547
RefSeq - XM_015288548
RefSeq - XM_015288549
RefSeq - XM_015288550
RefSeq - XM_015288551
RefSeq - XM_015288552
RefSeq - XM_015288553
RefSeq - XM_015288554
RefSeq - XM_015288555
RefSeq - XM_015288556
RefSeq - XM_015288557
RefSeq - XM_015288558
RefSeq - XM_015288559
RefSeq - XM_015288560
RefSeq - XM_015288561
RefSeq - XM_015288562
RefSeq - XM_015288563
RefSeq - XM_015288564
RefSeq - XM_015288565
RefSeq Peptide - NP_001193439
swissprot - E1BYU0
swissprot - F1NEB1
swissprot - A0A1D5P979
Ensembl - ENSGALG00000008883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf7l2ENSDARG00000004415Danio rerio
 Q9NQB0ENSG00000148737Homo sapiens
 Q924A0ENSMUSG00000024985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TCF7 / transcription factor 7 / P36402* / Q00417* / transcription factor 7, T cell specific*ENSGALG0000000648040
LEF1 / lymphoid enhancer binding factor 1 / P27782* / Q9UJU2*ENSGALG0000003196039


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028773  Transcription factor 7-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032350 regulation of hormone metabolic process IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043570 maintenance of DNA repeat elements IEA
 biological_processGO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0048625 myoblast fate commitment IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0070369 beta-catenin-TCF7L2 complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0070016 armadillo repeat domain binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003596 TRRAP / transformation/transcription domain associated protein / Q9Y4A5*  / complex / reaction
 ENSGALG00000037655 BCL9 / B cell CLL/lymphoma 9 / O00512* / Q9D219* / B-cell CLL/lymphoma 9 protein *  / complex / reaction
 ENSGALG00000032994 SOX17* / Q61473* / Q9H6I2* / SRY-box 17* / Transcription factor SOX-17 *  / complex / reaction
 ENSGALG00000012575 TLE1 / transducin like enhancer of split 1 / Q04724* / Q62440* / Transducin-like enhancer protein 1 *  / complex / reaction
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex
 ENSGALG00000004369 PYGO1 / pygopus family PHD finger 1 / Q9D0P5* / Q9Y3Y4* / pygopus 1*  / complex / reaction
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / complex / reaction
 ENSGALG00000005931 RUVBL1 / ruvB-like 1 / Q9Y265* / P60122* / RuvB-like protein 1* / RuvB like AAA ATPase 1*  / reaction / complex
 ENSGALG00000015184 TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *  / reaction / complex
 ENSGALG00000002469 CDC73 / Q5ZLM0 / Parafibromin / Q6P1J9* / Q8JZM7* / cell division cycle 73*  / reaction / complex
 ENSGALG00000005699 NLK / nemo like kinase / O54949* / Q9UBE8* / Serine/threonine-protein kinase NLK *  / reaction
 ENSGALG00000039942 CTBP1 / C-terminal-binding protein 1 / O88712* / Q13363*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr