ENSGALG00000005699


Gallus gallus

Features
Gene ID: ENSGALG00000005699
  
Biological name :NLK
  
Synonyms : nemo like kinase / NLK
  
Possible biological names infered from orthology : O54949 / Q9UBE8 / Serine/threonine-protein kinase NLK
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 9282142
Gene end: 9320098
  
Corresponding Affymetrix probe sets: Gga.5958.1.S1_at (Chicken Array)   Gga.5958.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009129
NCBI entrez gene - 417669     See in Manteia.
RefSeq - XM_015295865
RefSeq - XM_015295866
swissprot - F1N862
Ensembl - ENSGALG00000005699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlk2ENSDARG00000028793Danio rerio
 NLKENSG00000087095Homo sapiens
 NlkENSMUSG00000017376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*ENSGALG0000000150128
MAPK6 / Q5F3W3 / Mitogen-activated protein kinase 6 / Q16659* / Q61532*ENSGALG0000003144824
MAPK15 / mitogen-activated protein kinase 15 / Q80Y86* / Q8TD08*ENSGALG0000002927923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042501 serine phosphorylation of STAT protein IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050821 protein stabilization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA


Pathways (from Reactome)
Pathway description
Ca2+ pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005699 NLK / nemo like kinase / O54949* / Q9UBE8* / Serine/threonine-protein kinase NLK *  / complex / reaction
 ENSGALG00000008883 TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*  / reaction
 ENSGALG00000031960 LEF1 / lymphoid enhancer binding factor 1 / P27782* / Q9UJU2*  / reaction






 

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